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merck millipore,默克密理博,540220,Purmorphamine - CAS 483367-10-8 - Calbiochem
产品名称：Purmorphamine - CAS 483367-10-8 - Calbiochem
产品型号：540220
A cell-permeable 2,6,9-trisubstituted purine compound that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC₅₀ = 1 µM) and lineage-committed preosteoblasts M More>>
merck millipore,默克密理博,540220,Purmorphamine - CAS 483367-10-8 - Calbiochem
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重要规格表
经验配方 CAS号 C₃₁H₃₂N₆O₂ 483367-10-8 描述 概述 A cell-permeable 2,6,9-trisubstituted purine compound that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC50 = 1 µM) and lineage-committed preosteoblasts MC3T3-E1. Its effect can be synergized with that of BMP-4 (bone morphogenetic protein-4) and has been shown to induce transdifferentiation even in preadipocytes and myoblasts. Reported to induce osteogenesis by activation of the Hedgehog signaling pathway. A 50 mM (5 mg/192 µl) solution of Purmorphamine (Cat. No. 540223) in DMSO is also available.
Please note that the molecular weight for this compound is batch-specific due to variable water content.产品目录编号 540220 品牌系列 Calbiochem®
同义词 2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine, Shh Signaling Agonist 参考 参考 Wu, X., et al. 2004. Chem. Biol. 11, 1229.
Wu, X., et al. 2002. J. Am. Chem. Soc. 124, 14520.产品信息 CAS号 483367-10-8 具有ATP竞争性 N 形式 Off-white solid Hill配方 C₃₁H₃₂N₆O₂ 化学配方 C₃₁H₃₂N₆O₂ 可逆 N 结构配方图像 生物信息 主靶 Activation of the Hedgehog signaling pathway 主靶IC50 EC50 = 1 µM for inducing osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 安全信息 R相 R: 22-68
Harmful if swallowed.
Possible risks of irreversible effects.S相 S: 22-36/37
Do not breathe dust.
Wear suitable protective clothing and gloves.储存和货运信息 货运代码 Ambient Temperature Only
毒性 Harmful
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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