merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB3706,Anti-CD4 Antibody, intracellular, clone 024-10D6.B3

  • merck millipore,默克密理博,MAB3706,Anti-CD4 Antibody, intracellular, clone 024-10D6.B3

    产品名称：Anti-CD4 Antibody, intracellular, clone 024-10D6.B3
    产品型号：MAB3706
    Detect CD4 using this Anti-CD4 Antibody, intracellular, clone 024-10D6.B3 validated for use in ELISA, EMSA, FUNC & IC.

    merck millipore,默克密理博,MAB3706,Anti-CD4 Antibody, intracellular, clone 024-10D6.B3

  • 产品介绍
  • merck millipore,默克密理博,MAB3706,Anti-CD4 Antibody, intracellular, clone 024-10D6.B3

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICC, ELISA, EMSAMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB3706
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-CD4 Antibody, intracellular, clone 024-10D6.B3
    产品信息
    格式 Purified
    演示 Purified immunoglobulin. Liquid in 0.02 M phosphate buffer, 0.25M NaCl, with 0.1% sodium azide.
    应用
    应用 Detect CD4 using this Anti-CD4 Antibody, intracellular, clone 024-10D6.B3 validated for use in ELISA, EMSA, FUNC & IC.
    主要应用
    • Immunocytochemistry
    • ELISA
    • Electrophoretic Mobility Shift Assay
    应用说明 Immunocytochemistry

    ELISA

    Stimulation/Inhibition of biological activity

    Electrophoretic mobility shift analysis

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Synthetic peptide corresponding to amino acids 439-458 of the cytoplasmic tail of human CD4.
    表位 intracellular
    克隆 024-10D6.B3
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Recognizes the cytoplasmic tail of CD4. Many functions have been assigned to this tail, including anti-viral regulation (down/up regulation of CD4), T-cell maturation, activation and differentiation, and Lck signal transduction, among others. This antibody is useful as a control for studies involving targeting of intracellular protein domains of T cells.
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000616.3
    基因符号
    • CD4mut
    • CD4
    UniProt编号
    • P01730
    UniProt汇总 FUNCTION: SwissProt: P01730 # Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
    SIZE: 458 amino acids; 51111 Da
    SUBUNIT: Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI- CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu.
    SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
    PTM: Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
    SIMILARITY: SwissProt: P01730 ## Contains 3 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    MISCELLANEOUS: Primary receptor for HIV-1.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 2-8°C for up to 12 months from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB3706,Anti-CD4 Antibody, intracellular, clone 024-10D6.B3

上一件merck millipore产品：merck millipore,默克密理博,540220,Purmorphamine - CAS 483367-10-8 - Calbiochem
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