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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB10612 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-IASPP (CT) Antibody 背景信息 iASPP (inhibitor of apoptosis stimulating protein of p53, RelA-associated inhibitor (RAI), NFκB-interacting protein 1, protein phosphatase 1 regulatory subunit 13-like, PPP1R13L) is the third member of the ASPP family of proteins. Unlike ASPP1 and ASPP2, which interact with p53 and enhance its ability to induce apoptosis, iASPP inhibits apoptosis induced by p53 overexpression. iASPP has been identified in a yeast-two hybrid screen as an interacting protein of the p65 subunit of NFκB (RelA),3 interacts with NFκB in vivo, and acts as an efficient inhibitor of HIV-1 gene expression in which both NFκb and Sp1 play major roles. iASPP expression is upregulated in human breast carcinomas expressing wild-type p53, and gene overexpression may play an important role in the leukemogenesis and/or progression of acute leukemia. 产品信息 格式 Purified 演示 This polyclonal antibody is supplied in 400 μL of phosphate buffered saline (pH 7.4) containing 0.1% sodium azide. 应用 应用 Anti-IASPP (C-Terminal) Antibody is an antibody against IASPP (C-Terminal) for use in WB. 主要应用 - Western Blotting
应用说明 Western Blotting: 1-3 μg/mL 生物信息 免疫原品种 Synthetic peptide derived from the C-terminal region of the human, mouse, and bovine iASPP proteins. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes IASPP (C-Terminal). 品种反应性 Human Species Reactivity Note Human (positive controls: HEK293 and MCF-7 cell lysates). Based on sequence homology, reactivity with mouse and bovine is also expected. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_006663.2
Entrez基因汇总 IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM] 基因符号 - NKIP1
- PPP1R13L
- IASPP
- RAI
- PPP1R13BL
纯化方法 Immunoaffinity purified UniProt编号 - Q8WUF5
UniProt汇总 FUNCTION: SwissProt: Q8WUF5 # Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.
SIZE: 828 amino acids; 89091 Da
SUBUNIT: Interacts with RELA NF-kappa-B subunit and with SP1 via its C-terminus part. Interacts with p53/TP53.
SUBCELLULAR LOCATION: Isoform 1: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic but also nuclear (isoform 1). & Isoform 2: Nucleus.
TISSUE SPECIFICITY: Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte.
DOMAIN:SwissProt: Q8WUF5 The N-terminal region of isoform 1 is required for cytoplasmic localization.DISEASE:SwissProt: Q8WUF5 # Defects in PPP1R13L may be a cause of breast cancers. It is overexpressed in many patients suffering from breast carcinomas and expressing a wild-type p53/TP53 protein.
SIMILARITY: Belongs to the ASPP family. & Contains 2 ANK repeats. & Contains 1 SH3 domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Freeze -20°C. 包装信息 数量 100 µg
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