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品种反应性 主要应用 宿主 格式 抗体类型 Po, H, M, R, B, Eq, Rhesus Macaque, Chp WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB10527 描述 Anti-VDAC Antibody Alternate Names - Plasmalemmal porin
- voltage-dependent anion channel 1
- Porin 31HL
- Outer mitochondrial membrane protein porin 1
- PORIN-31-HL
- Porin 31HM
- voltage-dependent anion-selective channel protein 1
背景信息 Voltage-dependent anion-selective channel protein 1 (also known as VDAC, VDAC1 or outer mitochondrial membrane protein porin 1) is the the outer mitochondrial membrane receptor for hexokinase and BCL2L1. VDAC forms a channel through the mitochondrial membrane and is involved in small molecule diffusion, cell volume regulation and apoptosis. VDAC may participate in the formation of the permeability transition pore complex (PTPC), which is responsible for the release of mitochondrial products that triggers apoptosis. 产品信息 格式 Affinity Purified 控制 - HepG2 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-VDAC Antibody is validated for use in WB for the detection of VDAC. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human VDAC. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 PigHumanMouseRatBovineHorseRhesus MacaqueChimpanzee Species Reactivity Note Demonstrated to react with human, mouse, and rat.
Predicted to react with bovine, equine, rhesus macaque, chimpanzee, and porcine based on 100% sequence homology.抗体类型 Polyclonal Antibody Entrez基因编号 - NP_003365
Entrez基因汇总 This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y. 基因符号 - hVDAC1
- VDAC1
- VDAC
- PORIN1
纯化方法 Affinity Purified UniProt编号 - P21796
UniProt汇总 FUNCTION: Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
SUBUNIT STRUCTURE: Interacts with hexokinases By similarity. Interacts with BCL2L1. Interacts with influenza A virus PB1-F2 protein.
SUBCELLULAR LOCATION: Mitochondrion outer membrane. Cell membrane
TISSUE SPECIFICTY: Heart, liver and skeletal muscle.
DOMAIN: Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity.
SEQUENCE SIMILARITIES: Belongs to the eukaryotic mitochondrial porin family.产品使用声明 质量保证 Evaluated by Western Blot in HepG2 cell lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected VDAC in 10 µg of HepG2 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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