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品种反应性 主要应用 宿主 格式 抗体类型 M WB, ELISA Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB5126 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Melanocortin Receptor-1 Antibody 产品信息 格式 Affinity Purified 演示 Affinity Purified immunoglobulin. Liquid in PBS, 0.1% BSA and 0.05% sodium azide. 应用 应用 Anti-Melanocortin Receptor-1 Antibody is an antibody against Melanocortin Receptor-1 for use in ELISA & WB. 主要应用 - Western Blotting
- ELISA
应用说明 Western blot: 1-10 μg/mL using Chemiluminescence technique
ELISA: 1:10,000 - 100,000
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 A 21 mer peptide (designated MCR11) from the 3rd cytoplasmic domain of mouse MC1-R. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Melanocyte Stimulating Hormone Receptor (MSH-R), also called Melanotropin Receptor, or Melanocortin-1 Receptor (MC1-R), is a 315 aa transmembrane protein belonging to the family 1 of G-Protein coupled receptors. It is a receptor for MSH (a, b, g) and ACTH. Its activity is mediated by G-proteins that activate adenylate cyclase. It is found in Melanocytes and corticoadrenal tissue as well as various tissues like adrenal gland, leukocytes, lung, lymph node, ovary, testis, pituitary, placenta, spleen and uterus.
Mouse MSH-R. Reactivity with other species has not been confirmed. The immunogen sequence shows 70% homology with human, 66% with bovine, sheep and horse, and 60% with canine.品种反应性 Mouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002386.2
Entrez基因汇总 This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. 基因符号 - MC1-R
- MC1R
- MSHR
- MSH-R
- MGC14337
UniProt编号 - Q01726
UniProt汇总 FUNCTION: SwissProt: Q01726 # Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
SIZE: 317 amino acids; 34706 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Melanocytes and corticoadrenal tissue.
SIMILARITY: SwissProt: Q01726 ## Belongs to the G-protein coupled receptor 1 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Can be refrigerated at 2-8°C in undiluted aliquots for short term use. Maintain frozen at -20°C in undiluted aliquots for up to 12 months. 包装信息 数量 50 µg
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