merck millipore,默克密理愽
  • merck millipore,默克密理博,CBL430-KC,C-MYC, MS X HU (KC)

  • merck millipore,默克密理博,CBL430-KC,C-MYC, MS X HU (KC)

    产品名称：C-MYC, MS X HU (KC)
    产品型号：CBL430-KC


    merck millipore,默克密理博,CBL430-KC,C-MYC, MS X HU (KC)

  • 产品介绍
  • merck millipore,默克密理博,CBL430-KC,C-MYC, MS X HU (KC)

    描述
    产品目录编号 CBL430-KC
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 C-MYC, MS X HU (KC)
    概述 This product is intended for use by IVD manufacturers.
    产品信息
    格式 Purified
    演示 The monoclonal is presented at a concentration of 100μg/1ml in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application.
    应用
    主要应用
    • Western Blotting
    应用说明 Epitope tagging on sequence EQKLISEEDL

    Western blotting of myc-tagged recombinant proteins and re combinant myc

    Immunohistochemical staining of formalin and fixed paraffin embedded tissue sections and also acetone fixed frozen sections

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic peptide corresponding to the carboxy terminal of human c-myc
    表位 a.a. 408-438
    克隆 9E10
    宿主 Mouse
    特异性 KNOWN SPECIES CROSS REACTIVITY: Weakly cross-reactive with mouse but not rat
    同种型 IgG1
    品种反应性 MouseHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002467.3
    Entrez基因汇总 The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
    基因符号
    • c-Myc
    • MYC
    • C-MYC
    非反应性品种
    • Rat
    UniProt编号
    • P01106
    UniProt汇总 FUNCTION: SwissProt: P01106 # Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.
    SIZE: 439 amino acids; 48804 Da
    SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with JARID1A and JARID1B.
    SUBCELLULAR LOCATION: Nucleus.
    PTM: Phosphorylated by PRKDC.
    DISEASE: SwissProt: P01106 # Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. & A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.
    SIMILARITY: SwissProt: P01106 ## Contains 1 basic helix-loop-helix (bHLH) domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
    包装信息
    数量 Bulk packaging. Please inquire.

    merck millipore,默克密理博,CBL430-KC,C-MYC, MS X HU (KC)

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