merck millipore,默克密理愽
  • merck millipore,默克密理博,401474,IKK Inhibitor II, Wedelolactone - CAS 524-12-9 - Calbiochem

  • merck millipore,默克密理博,401474,IKK Inhibitor II, Wedelolactone - CAS 524-12-9 - Calbiochem

    产品名称：IKK Inhibitor II, Wedelolactone - CAS 524-12-9 - Calbiochem
    产品型号：401474
    The IKK Inhibitor II, Wedelolactone, also referenced under CAS 65646-68-6, controls the biological activity of IKK. This small molecule/inhibitor is primarily used for Inflammation/Immunology applicat More>>

    merck millipore,默克密理博,401474,IKK Inhibitor II, Wedelolactone - CAS 524-12-9 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,401474,IKK Inhibitor II, Wedelolactone - CAS 524-12-9 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₆H₁₀O₇524-12-9
    描述
    概述 The naturally isolated active ingredient of the herbal medicine, Eclipta alba, that acts as a cell permeable, selective and irreversible inhibitor of IKKα and β kinase activity (IC50 < 10 µM). Inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Has no effects on p38 MAP kinase or Akt.
    产品目录编号 401474
    品牌系列 Calbiochem®
    同义词 Wedelolactone, Eclipta alba, 7-Methoxy-5,11,12-trihydroxy-coumestan
    参考
    参考 Kobori, M., et al. 2004. Cell Death Differ. 11, 123.
    Li, C.C., et al. 2003. J. Org. Chem. 68, 8500.
    Mors, W.B., et al. 1989. Toxicon 27, 1003.
    Wagner, H., and Fessler, B. 1986. Planta Med. 5, 374.
    产品信息
    CAS号 524-12-9
    具有ATP竞争性 N
    形式 Yellowish-green, crystalline powder
    Hill配方 C₁₆H₁₀O₇
    化学配方 C₁₆H₁₀O₇
    Molar Mass 314.3
    可逆 N
    结构配方图像
    生物信息
    主靶 IKKα and β kinase activity
    主靶IC50 < 10 µM against IKKα and β kinase activity
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or MeOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,401474,IKK Inhibitor II, Wedelolactone - CAS 524-12-9 - Calbiochem

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