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品种反应性 主要应用 宿主 格式 抗体类型 M, R IHC, WB Rb Serum Polyclonal Antibody 描述 产品目录编号 AB10521 描述 Anti-Neuropilin-1 Antibody Alternate Names - Npn 1
- CD304 antigen
- Vascular endothelial cell growth factor 165 receptor
- neuropilin 1
- transmembrane receptor
背景信息 Neuropilin-1 is a type 1 membrane protein with three distinct functions. First, it can mediate cell adhesion via a heterophilic molecular interaction. Second, in neuronal cells, neuropilin-1 binds the class 3 semaphorins, which are neuronal chemorepellents, and plays a role in the directional guidance of axons. It is expected to form complexes with the plexinA subfamily members and mediate the semaphorin-elicited inhibitory signals into neurons. Third, in endothelial cells, neuropilin-1 binds a potent endothelial cell mitogen, vascular endothelial growth factor (VEGF)165, and regulates vessel formation. 产品信息 格式 Serum 控制 - PC12 cell lysate
演示 Rabbit serum in buffer containing 0.05% sodium azide. 应用 应用 This Anti-Neuropilin-1 Antibody is validated for use in WB, IH, IP, IF for the detection of Neuropilin-1. 主要应用 - Immunohistochemistry
- Western Blotting
生物信息 免疫原品种 This antibody is generated from rabbits immunized with a His-tagged partial recombinant rat Neuropilin-1. 表位 Unknown 宿主 Rabbit 特异性 This antibody recognizes Neuropilin-1. 同种型 IgG 品种反应性 MouseRat Species Reactivity Note Proven to react with mouse and rat. Human-94% homology 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_659566.1
Entrez基因汇总 NRP1 is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF; MIM 192240) and semaphorin (see SEMA3A; MIM 603961) family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion.[supplied by OMIM] 基因符号 - neuropilin-1
- NRP1
- NRP
- NP1
- BDCA4
- CD304
纯化方法 Unpurified UniProt编号 - Q9QWJ9
UniProt汇总 FUNCTION: Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis (By similarity).
SUBUNIT: Heterodimer with NRP2 (Probable). Binds PLXNB1 (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Found in the embryonic nervous system.
SIMILARITY: Belongs to the neuropilin family.
Contains 2 CUB domains.
Contains 2 F5/8 type domains.
Contains 1 MAM domain.产品使用声明 质量保证 Evaluated by Western Blot in PC12 cell lysate.
Western Blot Analysis: : 1:1,000 dilution of this antibody detected Neuropilin 1 on 10 µg of PC12 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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