merck millipore,默克密理愽
  • merck millipore,默克密理博,572660,SU11652 - CAS 326914-10-7 - Calbiochem

  • merck millipore,默克密理博,572660,SU11652 - CAS 326914-10-7 - Calbiochem

    产品名称：SU11652 - CAS 326914-10-7 - Calbiochem
    产品型号：572660
    A cell-permeable pyrrole-indolinone compound that acts as a potent, reversible, and ATP-competitive tyrosine kinase receptor and angiogenic inhibitor.

    merck millipore,默克密理博,572660,SU11652 - CAS 326914-10-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,572660,SU11652 - CAS 326914-10-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₂H₂₇ClN₄O₂326914-10-7
    描述
    概述 A cell-permeable pyrrole-indolinone compound that acts as a potent, reversible, and ATP-competitive tyrosine kinase receptor and angiogenic inhibitor that exhibits greater selectivity for PDGFRβ (IC50 = 3 nM), VEGFR2 (IC50 = 27 nM), FGFR1 (IC50 = 170 nM), and Kit family members (IC50 = ~ 10-500 nM) over EGFR (IC50 >20 µM). Reported to display anti-proliferative and pro-apoptotic properties in tumor cells.
    产品目录编号 572660
    品牌系列 Calbiochem®
    同义词 5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, VEGFR Tyrosine Kinase Inhibitor XVII, VEGFR2 Kinase Inhibitor XIV, PDGFR Tyrosine Kinase Inhibitor VIII
    参考
    参考 Heryanto, B., et al. 2003. Reproduction 125, 334.
    Sun, L., et al. 2003. J. Med. Chem. 46, 1116.
    Liao, A.T., et al. 2002. Blood 100, 585.
    产品信息
    CAS号 326914-10-7
    具有ATP竞争性 Y
    形式 Orange powder
    Hill配方 C₂₂H₂₇ClN₄O₂
    化学配方 C₂₂H₂₇ClN₄O₂
    Molar Mass 414.9
    可逆 Y
    结构配方图像
    生物信息
    主靶 PDGFRB
    主靶IC50 3 nM, 27 nM, 170 nM against PDGFRβ, VEGFR2, and FGFR1, respectively
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,572660,SU11652 - CAS 326914-10-7 - Calbiochem

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