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  • merck millipore,默克密理博,AB5590,Anti-Nicotinic Acetylcholine Receptor α4 Antibody

  • merck millipore,默克密理博,AB5590,Anti-Nicotinic Acetylcholine Receptor α4 Antibody

    产品名称：Anti-Nicotinic Acetylcholine Receptor α4 Antibody
    产品型号：AB5590
    This Anti-Nicotinic Acetylcholine Receptor α4 Antibody is validated for use in IH for the detection of Nicotinic Acetylcholine Receptor α4.

    merck millipore,默克密理博,AB5590,Anti-Nicotinic Acetylcholine Receptor α4 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5590,Anti-Nicotinic Acetylcholine Receptor α4 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    RIHCGpSerumPolyclonal Antibody
    描述
    产品目录编号 AB5590
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Nicotinic Acetylcholine Receptor α4 Antibody
    Alternate Names
    • nAChRalpha4
    产品信息
    格式 Serum
    演示 Guinea pig serum. Liquid. Contains no preservative.
    应用
    应用 This Anti-Nicotinic Acetylcholine Receptor α4 Antibody is validated for use in IH for the detection of Nicotinic Acetylcholine Receptor α4.
    主要应用
    • Immunohistochemistry
    应用说明 Immunohistochemistry: 1:1,000-1:2,000 using a Cy3 conjugated secondary antibody. The tissue was fixed in a paraformaldehyde/picric acid-mixture (4% paraformaldehyde and 0.4% picric acid in 0.16 M sodium phosphate buffer, pH 6.9). See application notes on back page.

    Western blot: not tested

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Synthetic peptide corresponding to amino acids 568-588 of the rat nAChR alpha4 protein.
    宿主 Guinea Pig
    特异性 Nicotinic Acetylcholine Receptor alpha4 (nAChR alpha4). The antibody stains nerve fibers and cell bodies in untreated animals. The staining pattern for the immunoreactive cell bodies obtained with AB5590 corresponds to the pattern described using in situ hybridization with probes to rat nAChR receptor mRNA. (Wada et al., 1989, 1990; Duvoisin et al., 1989; Dineley-Miller and Patrick, 1992; Seguela et al., 1993) as well as using antisera to nAChR (Mason, 1985; Swanson et al., 1987; Schroder et al., 1989; Bravo and Karten, 1992; Okuda et al., 1993; Dominguez del Toro et al., 1994; Nakayama et al., 1995; Goldner et al., 1997; Rogers et al., 1998; Sorenson et al., 1998; Arroyo-Jiménez et al., 1999). Strong nAChR a4 immunoreactivity is demonstrated in the Purkinje cells of the cerebellum, in neurons of the cerebral cortex, striatum, brainstem and spinal cord.

    SPECIES REACTIVITIES: It is expected that the antibody will also react with mouse and human based on sequence homology. Other species have not yet been tested.
    品种反应性 Rat
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000744.3
    Entrez基因汇总 The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. After binding acetylcholine, these pentameric receptors respond by undergoing an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The protein encoded by this gene is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene appear to account for a small proportion of the cases of nocturnal frontal lobe epilepsy.
    基因符号
    • EBN1
    • CHRNA4
    • NACRA4
    • BFNC
    • ENFL1
    • EBN
    UniProt编号
    • P43681
    UniProt汇总 FUNCTION: SwissProt: P43681 # After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
    SIZE: 627 amino acids; 69957 Da
    SUBUNIT: Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-4 subunit can be combined to beta- 2 or beta-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly.
    SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
    DISEASE:SwissProt: P43681 # Defects in CHRNA4 are the cause of autosomal dominant nocturnal frontal lobe epilepsy type 1 (ENFL1) [MIM:600513]; also symbolized ADNFLE. ENFL1 is a disease characterized by clusters of motor seizures during sleep.
    SIMILARITY: SwissProt: P43681 ## Belongs to the ligand-gated ionic channel (TC 1.A.9) family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µL

    merck millipore,默克密理博,AB5590,Anti-Nicotinic Acetylcholine Receptor α4 Antibody

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