merck millipore,默克密理愽
  • merck millipore,默克密理博,AB10514P,Anti-Serotonin Transporter Antibody

  • merck millipore,默克密理博,AB10514P,Anti-Serotonin Transporter Antibody

    产品名称：Anti-Serotonin Transporter Antibody
    产品型号：AB10514P
    This Anti-Serotonin Transporter Antibody is validated for use in WB for the detection of Serotonin Transporter.

    merck millipore,默克密理博,AB10514P,Anti-Serotonin Transporter Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB10514P,Anti-Serotonin Transporter Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, M, HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB10514P
    Replaces AB1594P
    描述 Anti-Serotonin Transporter Antibody
    Alternate Names
    • 5-hydroxytryptamine transporter
    • solute carrier family 6 (neurotransmitter transporter,<br />serotonin), member 4
    • sodium-dependent serotonin transporter
    • serotonin transporter
    • Solute carrier family 6 member 4
    • Na+/Cl- dependent serotonin transporter
    • 5HT transporter
    背景信息 This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
    产品信息
    格式 Affinity Purified
    控制
    • Western Blot : Human lung lysate.
    演示 Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.
    应用
    应用 This Anti-Serotonin Transporter Antibody is validated for use in WB for the detection of Serotonin Transporter.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human serotonin transporter.
    表位 Center region
    浓缩 1 mg/ml
    宿主 Rabbit
    特异性 The antibody reacts with the 70 kDa serotonin transporter protein.
    品种反应性 RatMouseHuman
    Species Reactivity Note Reacts with human, mouse and rat. Other species have not been tested. 100% homology to human, monkey, chimp, horse, mouse, rat, cow, sheep.
    抗体类型 Polyclonal Antibody
    基因符号
    • hSERT
    • 5-HTT
    • 5HTT
    • HTT
    • OCD1
    • SERT
    纯化方法 Antigen affinity purified
    UniProt编号
    • P31645
    UniProt汇总 FUNCTION: Terminates the action of serotonin by its high affinity sodium-dependent reuptake into presynaptic terminals.

    SUBUNIT STURCTURE: Interacts with TGFB1I1.

    SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.

    POLYMORPHISM: A polymorphism in the promoter region (5-HTT gene-linked polymorphic region, 5-HTTLPR) is located approximately 1 kb upstream of the transcription initiation site and is composed of 16 repeat elements. The polymorphism consists of a 44-bp insertion or deletion involving repeat elements 6 to 8. The short allele is associated with lower transcriptional efficiency of the promoter compared with the long allele. Over half of the Caucasian population has a short allele. Individuals with one or two copies of the short allele exhibit more depressive symptoms, diagnosable depression and suicidality in relation to stressful life events than individuals homozygous for the long allele.

    The polymorphism Val-425 seems to be linked to a susceptibility to obsessive-compulsive disorder (OCD) [MIM:164230].

    Genetic variations in SLC6A4 determine the genetic susceptibility to alcoholism [MIM:103780].

    MISCELLANEOUS: This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

    SEQUENCE SIMILARITIES: Belongs to the sodium:neurotransmitter symporter (SNF) family.
    产品使用声明
    质量保证 Western Blot Analysis: 1:1000 dilution of this antibody detected serotonin transporter on human lung lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Store at 2-8°C for 1 year from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB10514P,Anti-Serotonin Transporter Antibody

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