merck millipore,默克密理愽
  • merck millipore,默克密理博,528884,Polo-like Kinase Inhibitor V, Poloxin - CAS 321688-88-4 - Calbiochem

  • merck millipore,默克密理博,528884,Polo-like Kinase Inhibitor V, Poloxin - CAS 321688-88-4 - Calbiochem

    产品名称：Polo-like Kinase Inhibitor V, Poloxin - CAS 321688-88-4 - Calbiochem
    产品型号：528884
    The Polo-like Kinase Inhibitor V, Poloxin, also referenced under CAS 321688-88-4, controls the biological activity of Polo-like Kinase. This small molecule/inhibitor is primarily used for Phosphorylat More>>

    merck millipore,默克密理博,528884,Polo-like Kinase Inhibitor V, Poloxin - CAS 321688-88-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,528884,Polo-like Kinase Inhibitor V, Poloxin - CAS 321688-88-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₈H₁₉NO₃321688-88-4
    描述
    概述 A thymoquinone derivative, non-ATP competitive Polo-like Kinase 1 (Plk1) inhibitor specifically targeting the polo-box domain (PBD) of Plk1 (IC50) = 4.8 µM. Reduces both chromosome and kinetochoral localization of Plk1, induces chromosome congression defects , mitotic arrest in prometaphase, and apoptosis in HeLa cells at 25 µM. Exhibits anti-proliferative effects in a range of cancer cell lines, and in a mouse Xenograft model involving HeLa and MDA-MB-231 cells at 40 mg/kg.
    产品目录编号 528884
    品牌系列 Calbiochem®
    同义词 Polo-like Kinase Inhibitor V, 2-isopropyl-5-methyl-4-(2-methylbenzoyloxyimino)cyclohexa-2,5-dienone
    参考
    参考 Reindl, W., et al. 2008. Chem Biol. 15, 459.
    Yuan, J., et al. 2011, Am J Pathol 179, 2091.
    产品信息
    CAS号 321688-88-4
    形式 Yellow solid
    Hill配方 C₁₈H₁₉NO₃
    化学配方 C₁₈H₁₉NO₃
    Molar Mass 297.35
    结构配方图像
    生物信息
    纯度 ≥99% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,528884,Polo-like Kinase Inhibitor V, Poloxin - CAS 321688-88-4 - Calbiochem

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下一件merck millipore产品：merck millipore,默克密理博,5450-OP,OmniPur L-Histidine - Calbiochem


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