merck millipore,默克密理愽
  • merck millipore,默克密理博,AB10423,Anti-Phospho- Bad (Ser75) Antibody

  • merck millipore,默克密理博,AB10423,Anti-Phospho- Bad (Ser75) Antibody

    产品名称：Anti-Phospho- Bad (Ser75) Antibody
    产品型号：AB10423
    Anti-Phospho-Bad (Ser75) Antibody detects level of Phospho-Bad (Ser75) & has been published & validated for use in WB.

    merck millipore,默克密理博,AB10423,Anti-Phospho- Bad (Ser75) Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB10423,Anti-Phospho- Bad (Ser75) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, MWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 AB10423
    描述 Anti-Phospho- Bad (Ser75) Antibody
    Alternate Names
    • Bcl-XL/Bcl-2-associated death promoter
    • BCL-X/BCL-2 binding protein
    • BCL2-antagonist of cell death protein
    • BCL2-associated agonist of cell death
    • BCL2-binding component 6
    • BCL2-binding protein
    • Bcl-2-binding component 6
    • Bcl-2-like 8 protein
    背景信息 Bad is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin are found to be involved in the regulation of this protein. Bad is phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation.
    产品信息
    格式 Purified
    控制
    • Western Blot : RAW264.7/LPS lysate.
    演示 Purified immunoglobulins in PBS with 0.09% NaN3.
    应用
    应用 Anti-Phospho-Bad (Ser75) Antibody detects level of Phospho-Bad (Ser75) & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 This antibody is generated in rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS75 of human Bad.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody reacts with the 18 kDa phospho-Bad (Ser75) protein.
    品种反应性 RatMouse
    Species Reactivity Note Reacts with mouse and rat. Other species have not been tested. Predicted to react with human based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_116784
    Entrez基因汇总 The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq]
    基因符号
    • BCL2L8
    • BBC2
    • BBC6
    修改
    • Phosphorylation
    纯化方法 Protein G followed by IAP
    UniProt编号
    • Q92934
    UniProt汇总 FUNCTION: Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 By similarity. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
    SUBUNIT STRUCTURE: Forms heterodimers with the anti-apoptotic proteins, Bcl-X(L), Bcl-2 and Bcl-W. Also binds protein S100A10 By similarity. The Ser-75/Ser-99 phosphorylated form binds 14-3-3 proteins By similarity.
    SUBCELLULAR LOCATION: Mitochondrion outer membrane. Cytoplasm. Note= Upon phosphorylation, locates to the cytoplasm.
    TISSUE SPECIFICTY: Expressed in a wide variety of tissues.
    DOMAIN: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
    PTM: Phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation By similarity.
    SEQUENCE SIMILARITIES: Belongs to the Bcl-2 family.
    SEQUENCE CAUTION: The sequence AAB36516.1 differs from that shown. Reason: Frameshift at positions 64 and 91.
    产品使用声明
    质量保证 Western Blot Analysis: 1:250 dilution of this antibody detected phospho-Bad (Ser75) in lysate from LPS-stimulated RAW264.7 cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Store at 2-8°C for 6 months from date of receipt. For long term storage, store at -20°C
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB10423,Anti-Phospho- Bad (Ser75) Antibody

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