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  • merck millipore,默克密理博,MABN741,Anti-TrpV3 cation channel Antibody, clone N15/4

  • merck millipore,默克密理博,MABN741,Anti-TrpV3 cation channel Antibody, clone N15/4

    产品名称：Anti-TrpV3 cation channel Antibody, clone N15/4
    产品型号：MABN741
    Anti-TrpV3 cation channel Antibody, clone N15/4 is a highly specific mouse monoclonal antibody, that targets TrpV3 & has been tested in western blotting, IHC & ICC.

    merck millipore,默克密理博,MABN741,Anti-TrpV3 cation channel Antibody, clone N15/4

  • 产品介绍
  • merck millipore,默克密理博,MABN741,Anti-TrpV3 cation channel Antibody, clone N15/4

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HICC, WB, IHCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABN741
    描述 Anti-TrpV3 cation channel Antibody, clone N15/4
    Alternate Names
    • Protein Trpv3
    背景信息 The protein named Transient receptor potential cation channel subfamily V member 3 or TrpV3, or alternatively Vanilloid receptor-like 3 (VRL-3) and encoded by the human gene TRPV3 is a non-selective cation channel important in temperature sensation and vasoregulation. TrpV3 is expressed for instance in the sensory neurons of the skin and is activated by temperature. TrpV3 also plays a role in keratinocytes proliferation in hair growth; TrpV3 suppression promotes growth, over activation results in apoptosis and hair follicle regression. Indeed TrpV3 is often deemed the most important TRP (transient receptor potential) channel in keratinocytes of the skin. TrpV3 is widely expressed in the CNS and in the keratinocytes of the skin and epithelial tissues. In the brain TrpV3 channels appear to be important for mood regulation and TrpV3 appears to modulate some anti-inflammatory responses in the brain mediated by the anti-inflammatory agent incensole acetate. TrpV3 is also regulated by calcium, ATP and calmodulin, and while it is considered a temperature sensor, recent research challenges that somewhat but TrpV3 still plays important roles in other skin functions such as cutaneous sensations, hair development and barrier function, and mutations in TrpV3 have been linked to a rare genodermatosis known as the Olmsted syndrome.
    产品信息
    格式 Purified
    演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-TrpV3 cation channel Antibody, clone N15/4 is a highly specific mouse monoclonal antibody, that targets TrpV3 & has been tested in western blotting, IHC & ICC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    • Immunohistochemistry
    应用说明 Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TrpV3 cation channel in human cerebral cortex tissue.
    Immunocytochemistry Analysis: A representative lot detected TrpV3 cation channel in HEK293 cells (Prof. J. Trimmer, University of California, Davis).
    生物信息
    免疫原品种 Linear peptide corresponding to the C-terminus of rat TrpV3 cation channel.
    表位 C-terminus
    克隆 N15/4
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG2aκ
    品种反应性 MouseHuman
    Species Reactivity Note Human, Mouse. Predicted to react with Rat based on 100% sequence homology.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001020928
    基因符号
    • Trpv3
    纯化方法 Protein G purified
    UniProt编号
    • E9PU00
    产品使用声明
    质量保证 Evaluated by Western Blotting in Neuro-2a cell lysate.

    Western Blotting Analysis: 2.0 µg/mL of this antibody detected TrpV3 cation channel in 10 µg of Neuro-2a cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABN741,Anti-TrpV3 cation channel Antibody, clone N15/4

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