merck millipore,默克密理博,382425,Trequinsin, Hydrochloride - CAS 78416-81-6

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

当前位置：首页 > >Merck Millipore > 生命科学研究
生命科学研究

merck millipore,默克密理博,382425,Trequinsin, Hydrochloride - CAS 78416-81-6 - Calbiochem
产品名称：Trequinsin, Hydrochloride - CAS 78416-81-6 - Calbiochem
产品型号：382425
Extremely potent and cell-permeable inhibitor of cGMP-inhibited phosphodiesterase (IC₅₀ = 300 pM) and platelet aggregation in vitro.

merck millipore,默克密理博,382425,Trequinsin, Hydrochloride - CAS 78416-81-6 - Calbiochem

产品介绍

merck millipore,默克密理博,382425,Trequinsin, Hydrochloride - CAS 78416-81-6 - Calbiochem

重要规格表

经验配方	CAS号
C₂₄H₂₇N₃O₃ · HCl	78416-81-6

描述
概述	Extremely potent and cell-permeable inhibitor of cGMP-inhibited phosphodiesterase (IC₅₀ = 300 pM) and platelet aggregation in vitro. Potentiates adenosine-stimulated cAMP accumulation.
产品目录编号	382425
品牌系列	Calbiochem®
同义词	9,10-Dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4H-pyrimido-(6,1-a)-isoquinolin-4-one, HCl, HL 725

参考
参考	Spina, D., et al. 1998. Life Sci. 62, 953. Pillai, R., et al. 1994. J. Biol. Chem. 269, 30676. Tang, K.M., et al. 1994. Eur. J. Pharmacol. 268, 105. Whalin, M.E., et al. 1991. Mol. Pharmacol. 39, 711. Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150. DeClerck, F., et al. 1990. Blood Coag. Fibrinol. 1, 247. Konkle, B.A., et al. 1990. J. Biol. Chem. 265, 21867. Ruppert, D., and Weithmann, K.U. 1982. Life Sci. 31, 2037.

参考

Spina, D., et al. 1998. Life Sci. 62, 953.
Pillai, R., et al. 1994. J. Biol. Chem. 269, 30676.
Tang, K.M., et al. 1994. Eur. J. Pharmacol. 268, 105.
Whalin, M.E., et al. 1991. Mol. Pharmacol. 39, 711.
Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150.
DeClerck, F., et al. 1990. Blood Coag. Fibrinol. 1, 247.
Konkle, B.A., et al. 1990. J. Biol. Chem. 265, 21867.
Ruppert, D., and Weithmann, K.U. 1982. Life Sci. 31, 2037.

产品信息
CAS号	78416-81-6
具有ATP竞争性	N
形式	Pale yellow solid
Hill配方	C₂₄H₂₇N₃O₃ · HCl
化学配方	C₂₄H₂₇N₃O₃ · HCl
Molar Mass	442.0
可逆	N
结构配方图像

生物信息
主靶	cGMP-inhibited phosphodiesterase
主靶IC₅₀	300 pM against cGMP-inhibited phosphodiesterase
纯度	≥98% by HPLC

理化信息
细胞可渗透	Y
溶解度	H₂O

GHS安全信息
RTECS	UW7727000

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+15°C to +30°C
防潮	Protect from moisture
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.