merck millipore,默克密理愽
  • merck millipore,默克密理博,AB10303,Anti-CAR Antibody

  • merck millipore,默克密理博,AB10303,Anti-CAR Antibody

    产品名称：Anti-CAR Antibody
    产品型号：AB10303
    Detect CAR using this Anti-CAR Antibody validated for use in WB.

    merck millipore,默克密理博,AB10303,Anti-CAR Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB10303,Anti-CAR Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbSerumPolyclonal Antibody
    描述
    产品目录编号 AB10303
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-CAR Antibody
    Alternate Names
    • constitutive androstane receptor
    背景信息 The constitutive androstane receptor (CAR) plays a key role in the control of drug metabolism and transport. Its exact functionality is still under investigation and it is believed to function with PXR in the processing of xenobiotics.
    产品信息
    格式 Serum
    演示 Raw rabbit serum with 0.1% sodium azide.
    应用
    应用 Detect CAR using this Anti-CAR Antibody validated for use in WB.
    主要应用
    • Western Blotting
    应用说明 Suggested dilutions:
    Western Blot: 1:5000
    生物信息
    免疫原品种 Recombinant human hCAR
    宿主 Rabbit
    同种型 IgG2b
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_005122.3
    • NM_001077469.1
    • NM_001077470.1
    • NM_001077471.1
    • NM_001077472.1
    • NM_001077473.1
    • NM_001077474.1
    • NM_001077475.1
    • NM_001077476.1
    • NM_001077477.1
    • NM_001077478.1
    • NM_001077479.1
    • NM_001077480.1
    • NM_001077481.1
    • NM_001077482.1
    Entrez基因汇总 This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.
    基因符号
    • MGC97144
    • NR1I3
    • MB67
    • CAR
    • CAR1
    • MGC97209
    • MGC150433
    • CARA
    UniProt编号
    • Q14994
    UniProt汇总 FUNCTION: SwissProt: Q14994 # Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
    SIZE: 352 amino acids; 39942 Da
    SUBUNIT: Heterodimer of NR1I3 and RXR. Interacts with PSMC4.
    SUBCELLULAR LOCATION: Nucleus (By similarity).
    TISSUE SPECIFICITY: Predominantly expressed in liver.
    DOMAIN:SwissProt: Q14994 Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains.
    SIMILARITY: Belongs to the nuclear hormone receptor family. NR1 subfamily. & Contains 1 nuclear receptor DNA-binding domain.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 2-8°C for up to 12 months from date of receipt.
    包装信息
    数量 50 µL

    merck millipore,默克密理博,AB10303,Anti-CAR Antibody

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