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merck millipore,默克密理博,138001,D-Amino Acid Oxidase Inhibitor II, CBIO - CAS 61977-29-5 - Calbiochem
产品名称：D-Amino Acid Oxidase Inhibitor II, CBIO - CAS 61977-29-5 - Calbiochem
产品型号：138001
The D-Amino Acid Oxidase Inhibitor II, CBIO, also referenced under CAS 61977-29-5, controls the biological activity of D-Amino Acid Oxidase.
merck millipore,默克密理博,138001,D-Amino Acid Oxidase Inhibitor II, CBIO - CAS 61977-29-5 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₇H₄ClNO₂ 61977-29-5 描述 概述 A cell-permeable benzisoxazolone compound that potently inhibits D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) activity (IC50 = 90 and 150/188 nM against rat spinal cord and porcine kidney DAO, respectively) in a reversible and D-serine-competitive (Ki = 100 nM) manner. Upon co-administration, CBIO (30 mg/kg, p.o.) markedly prolongs the half-life of orally administered D-serine (30 mg/kg) in plasma, resulting in enhanced rat brain D-serine level (60% vs. 25% above basal, respectively, with vs. without CBIO). Direct intrathecal/spinal CBIO injection either before (ED50 =60 ng) or after (ED50 = 170 ng) subcutaneous formalin injection (50 µl 5% solution) greatly alleviates formalin-induced late phase tonic pain (Emax =67%), but not early phase acute nociception in rats in vivo. 产品目录编号 138001 品牌系列 Calbiochem®
同义词 6-Chloro-1,2-benzisoxazol-3(2H)-one, 6-Chlorobenzo[d]isoxazol-3-ol, D-AAO Inhibitor II, CBIO 参考 参考 Gong, N., et al. 2011. J. Pharmacol. Exp. Ther. 336, 282.
Ferraris, D., et al. 2008. J. Med. Chem. 51, 3357.产品信息 CAS号 61977-29-5 形式 Off-white powder Hill配方 C₇H₄ClNO₂ 化学配方 C₇H₄ClNO₂ Molar Mass 169.6 结构配方图像 生物信息 纯度 ≥97% by HPLC 理化信息 溶解度 DMSO 安全信息 R相 R: 36/37/38
Irritating to eyes, respiratory system and skin.储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Irritant
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,494459,n-Octyl-β-D-glucopyranoside - CAS 29836-26-8 - Calbiochem
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