merck millipore,默克密理愽
  • merck millipore,默克密理博,MABT59,Anti-human CD151 clone TS151 Antibody

  • merck millipore,默克密理博,MABT59,Anti-human CD151 clone TS151 Antibody

    产品名称：Anti-human CD151 clone TS151 Antibody
    产品型号：MABT59
    Anti-human CD151 clone TS151 Antibody detects level of human CD151 clone TS151 & has been published & validated for use in FC & IP.

    merck millipore,默克密理博,MABT59,Anti-human CD151 clone TS151 Antibody

  • 产品介绍
  • merck millipore,默克密理博,MABT59,Anti-human CD151 clone TS151 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABT59
    描述 Anti-human CD151 clone TS151 Antibody
    Alternate Names
    • Tetraspanin-24
    • CD151 molecule (Raph blood group)
    • CD151 antigen
    • hemidesmosomal tetraspanin CD151
    • platelet-endothelial cell tetraspan antigen 3
    • CD151 antigen (Raph blood group)
    • tetraspanin-24
    • platelet surface glycoprotein gp27
    • Membrane glycoprotein SFA-1
    • Platelet-endothelial tetraspan antigen 3
    背景信息 CD151 is a tetraspanin and is thought to aid in the creation of multi-protein complexes at the surface of cells. CD151 forms secure laminin-binding compounds in the kidney, using integrins alpha3beta1 and alpha6beta1, and in the skin, using alpha3beta1 and alpha6beta4. CD151 may also play an important role in the inner ear and may also be involved in erythropoiesis. CD151 may be an important marker for prostate cancer and the higher the level of CD151, the less likely the patient survives. Research has shown that mice lacking CD151 have a damaged re-epithelialization process and lack wound healing ability.
    产品信息
    格式 Purified
    控制
    • HeLa cells
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-human CD151 clone TS151 Antibody detects level of human CD151 clone TS151 & has been published & validated for use in FC & IP.
    主要应用
    • Flow Cytometry
    应用说明 Immunoprecipitation Analysis: A previous lot was used by an independent laboratory to immunoprecipitate CD151 from a Brij97 lysate of HeLa cells (Charrin, S., et al. (2001). The Biological journal of Chemistry. 276(17):14329–14337) and a Brij97 lysate of Daudi cells transfected with integrin alpha3beta1 (Charrin, S., et al. (2003). Biochemical and Biophysical Research Communications 304:107–112).
    生物信息
    免疫原品种 Whole HeLa cells
    克隆 TS151
    宿主 Mouse
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001034579
    Entrez基因汇总 The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq].
    基因符号
    • PETA3
    • CD151
    • SFA1
    • SFA-1
    • TSPAN24
    • PETA-3
    • RAPH
    • tspan-24
    • Tspan-24
    • GP27
    • MER2
    纯化方法 Protein G Purified
    UniProt编号
    • P48509
    UniProt汇总 FUNCTION: Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.

    SUBUNIT STRUCTURE: Interacts with integrins alpha3beta1, alpha5beta1, alpha3beta1 and alpha6beta4, with CD9 and CD181.

    SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.

    TISSUE SPECIFICTY: Expressed in a variety of tissues including vascular endothelium and epidermis. Expressed on erythroid cells, with a higher level of expression in erythroid precursors than on mature erythrocytes.

    INDUCTION: By HTLV-1.

    POLYMORPHISM: CD151 defines the MER2=RAPH1 antigen of the RAPH blood group system. 92% of Caucasians are MER2-positive and 8% are apparently MER2-negative.

    IINVOLVEMENT IN DISEASE: Defects in CD151 are the cause of nephropathy with pretibial epidermolysis bullosa and deafness (NPEBD) [MIM:609057]. NPEBD is characterized by the association of hereditary nephritis, epidermolysis bullosa, deafness, and beta-thalassemia minor.

    SEQUENCE SIMILARITIES: Belongs to the tetraspanin (TM4SF) family.
    产品使用声明
    质量保证 Evaluated by Flow Cytometry in HeLa cells.

    Flow Cytometry Analysis: A 1:100 dilution of this antibody detected CD151 in HeLa cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MABT59,Anti-human CD151 clone TS151 Antibody

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