merck millipore,默克密理愽
  • merck millipore,默克密理博,AB9598,Anti-Glial fibrillary acidic protein δ Antibody

  • merck millipore,默克密理博,AB9598,Anti-Glial fibrillary acidic protein δ Antibody

    产品名称：Anti-Glial fibrillary acidic protein δ Antibody
    产品型号：AB9598
    Anti-Glial fibrillary acidic protein δ Antibody is an antibody against Glial fibrillary acidic protein δ for use in WB, IH(P).

    merck millipore,默克密理博,AB9598,Anti-Glial fibrillary acidic protein δ Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB9598,Anti-Glial fibrillary acidic protein δ Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbSerumPolyclonal Antibody
    描述
    产品目录编号 AB9598
    Replaces 04-1031; 04-1062
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Glial fibrillary acidic protein δ Antibody
    Alternate Names
    • GFAPdelta
    背景信息 Human Glial Fibrillary Acidic Protein delta (GFAP-delta) is a GFAP protein isoform that is encoded by an alternative splice variant of the GFAP-gene. As a result, GFAP-delta protein differs from the predominant splice form, GFAP-alpha, by its C-terminal protein sequence. GFAP-delta protein is not expressed by all GFAP expressing astrocytes but specifically by a subpopulation located in the subpial zone of the cerebral cortex, the subgranular zone of the hippocampus and, most intensely, by a ribbon of astrocytes following the ependymal layer of the cerebral ventricles. Therefore, at least in the sub ventricular zone (SVZ), GFAP-delta specifically marks the population of astrocytes that contain the neural stem cells in the adult human brain. Interestingly, the SVZ astrocytes actively splice GFAP-delta transcripts, in contrast to astrocytes adjacent to this layer. Data shows that GFAP-delta protein, unlike GFAP-alpha, is not upregulated in astrogliosis. Data indicates a different functional role for GFAP-delta in astrocyte physiology. Transfection studies showed that GFAP-delta protein expression has a negative effect on GFAP filament formation, and therefore could be important for modulating intermediate filament cytoskeletal properties, possibly facilitating astrocyte motility. Further studies on GFAP-delta and the cells that express it are important for gaining insights into its function during differentiation, migration and during health and disease (Roelofs, RF, et al., Glia (2005) 52:289-300.).
    产品信息
    格式 Serum
    演示 Rabbit serum. Liquid.
    应用
    应用 Anti-Glial fibrillary acidic protein δ Antibody is an antibody against Glial fibrillary acidic protein δ for use in WB, IH(P).
    主要应用
    • Western Blotting
    应用说明 Western blot: 1:500 with overnight incubation. The antibody recognizes the ~60 kDa GFAP-delta protein.

    Immunohistochemistry: 1:500 incubated for 36-48 hours at 2-8°C on paraffin embedded tissue sections. It is suggested that the tissue be treated with microwave antigen retrieval prior to staining.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic peptide from human GFAP-delta.
    宿主 Rabbit
    特异性 Glial Fibrillary Acidic Protein-delta (GFAP-delta). The antibody does not recognize GFAP-alpha protein.
    品种反应性 Human
    Species Reactivity Note Does NOT react with mouse or rat GFAP-delta.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_002055.2
    Entrez基因汇总 This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. An additional transcript variant has been described, but its full length sequence has not been determined.
    基因符号
    • FLJ45472
    • GFAP
    UniProt编号
    • P14136
    UniProt汇总 FUNCTION: SwissProt: P14136 # GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
    SIZE: 432 amino acids; 49880 Da
    SUBUNIT: Isoform 3 interacts with N-terminus of PSEN1.
    SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with intermediate filaments.
    DISEASE: SwissProt: P14136 # Defects in GFAP are a cause of Alexander disease [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.
    SIMILARITY: SwissProt: P14136 ## Belongs to the intermediate filament family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB9598,Anti-Glial fibrillary acidic protein δ Antibody

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