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merck millipore,默克密理博,681674,Wnt Pathway Inhibitor XI, CCT036477 - CAS 305372-78-5 - Calbiochem
产品名称:Wnt Pathway Inhibitor XI, CCT036477 - CAS 305372-78-5 - Calbiochem
产品型号:681674
The Wnt Pathway Inhibitor XI, CCT036477, also referenced under CAS 305372-78-5, controls the biological activity of Wnt Pathway. This small molecule/inhibitor is primarily used for Cancer applications More>>
merck millipore,默克密理博,681674,Wnt Pathway Inhibitor XI, CCT036477 - CAS 305372-78-5 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₁H₁₈ClN₃ 305372-78-5 描述 概述 A cell-permeable indole derivative that acts as an inhibitor of Wnt signaling and exhibits an inhibitory effect in a reporter cell line (IC50 = 4.6 µM) and demonstrates growth inhibition in multiple cancer cell lines, not by altering β-catenin accumulation but by blocking transcription at the β-catenin level. Displays reduced expression of Wnt target genes in myc and survivin-luciferase reporter assays, and exhibits in vivo activity by blocking the development of zebrafish at 20 µM and Xenopus embryos at 75 µM. 产品目录编号 681674 品牌系列 Calbiochem®
同义词 CCT036477, CRT Inhibitor VI, β-Catenin/Tcf Inhibitor VI 参考 参考 Ewan, K., et al. 2010. Cancer Res. 70, 5963. 产品信息 CAS号 305372-78-5 形式 Off-white solid Hill配方 C₂₁H₁₈ClN₃ 化学配方 C₂₁H₁₈ClN₃ Molar Mass 347.84 结构配方图像 生物信息 纯度 ≥95% by 1H NMR 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following recontitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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