• merck millipore,默克密理博,681674,Wnt Pathway Inhibitor XI, CCT036477 - CAS 305372-78-5 - Calbiochem
  • merck millipore,默克密理博,681674,Wnt Pathway Inhibitor XI, CCT036477 - CAS 305372-78-5 - Calbiochem

    产品名称:Wnt Pathway Inhibitor XI, CCT036477 - CAS 305372-78-5 - Calbiochem
    产品型号:681674
    The Wnt Pathway Inhibitor XI, CCT036477, also referenced under CAS 305372-78-5, controls the biological activity of Wnt Pathway. This small molecule/inhibitor is primarily used for Cancer applications More>>

    merck millipore,默克密理博,681674,Wnt Pathway Inhibitor XI, CCT036477 - CAS 305372-78-5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,681674,Wnt Pathway Inhibitor XI, CCT036477 - CAS 305372-78-5 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₁H₁₈ClN₃305372-78-5
    描述
    概述 A cell-permeable indole derivative that acts as an inhibitor of Wnt signaling and exhibits an inhibitory effect in a reporter cell line (IC50 = 4.6 µM) and demonstrates growth inhibition in multiple cancer cell lines, not by altering β-catenin accumulation but by blocking transcription at the β-catenin level. Displays reduced expression of Wnt target genes in myc and survivin-luciferase reporter assays, and exhibits in vivo activity by blocking the development of zebrafish at 20 µM and Xenopus embryos at 75 µM.
    产品目录编号 681674
    品牌系列 Calbiochem®
    同义词 CCT036477, CRT Inhibitor VI, β-Catenin/Tcf Inhibitor VI
    参考
    参考 Ewan, K., et al. 2010. Cancer Res. 70, 5963.
    产品信息
    CAS号 305372-78-5
    形式 Off-white solid
    Hill配方 C₂₁H₁₈ClN₃
    化学配方 C₂₁H₁₈ClN₃
    Molar Mass 347.84
    结构配方图像
    生物信息
    纯度 ≥95% by 1H NMR
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following recontitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,681674,Wnt Pathway Inhibitor XI, CCT036477 - CAS 305372-78-5 - Calbiochem

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