merck millipore,默克密理愽
  • merck millipore,默克密理博,AB10130,Anti-NR1D1 (Rev-ErbA α) Antibody

  • merck millipore,默克密理博,AB10130,Anti-NR1D1 (Rev-ErbA α) Antibody

    产品名称：Anti-NR1D1 (Rev-ErbA α) Antibody
    产品型号：AB10130
    Anti-NR1D1 (Rev-ErbA α) Antibody is a Rabbit Polyclonal Antibody for detection of NR1D1 (Rev-ErbA α) also known as V-erbA-related protein EAR-1 & has been validated in WB.

    merck millipore,默克密理博,AB10130,Anti-NR1D1 (Rev-ErbA α) Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB10130,Anti-NR1D1 (Rev-ErbA α) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB10130
    描述 Anti-NR1D1 (Rev-ErbA α) Antibody
    Alternate Names
    • thyroid hormone receptor, alpha-like
    • V-erbA-related protein EAR-1
    • nuclear receptor subfamily 1, group D, member 1
    背景信息 Rev-ErbA alpha (NR1D1 or nuclear receptor subfamily 1, group D, member 1), is a member of the Rev-ErbA family of nuclear receptors and is a transcriptional repressor. In mammals, Rev-Erbα is highly expressed in the liver, skeletal muscle, adipose tissue, and the brain, participating in the development and circadian regulation of these tissues. Rev-Erbα regulates gene transcription by directly binding to target response elements (RevREs), comprises an A/T-rich flank followed by AGGTCA. Rev-Erbα mediates repression by recruiting the corepressor N-CoR, which then activates the histone deacetylase (HDAC) 3. A number of target genes has been identified for Rev-Erbα, including the lipoproteins ApoA1 and ApoCIII, hydratase dehydrogenase, the circadian factor BMAL, and the anti-fibrinolytic factor PAI-1. Many of these genes are coordinately regulated by Rev-erbα and the RAR-related orphan receptor RORα, which share the same response elements but exert opposite effects on gene transcription. Crosstalk between Rev-Erbα and RORα likely acts to fine-tune of their target physiologic networks, such as circadian rhythms, metabolic homeostasis, and inflammation.
    产品信息
    格式 Affinity Purified
    控制
    • A431 cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-glycine, pH 7.4, 0.150 mM NaCl and 0.05% sodium azide.
    应用
    应用 Anti-NR1D1 (Rev-ErbA α) Antibody is a Rabbit Polyclonal Antibody for detection of NR1D1 (Rev-ErbA α) also known as V-erbA-related protein EAR-1 & has been validated in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to residues surrounding the area near the N-terminus region of NR1D1.
    表位 Near N-terminus
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes NR1D1 near the N-terminus.
    品种反应性 Human
    Species Reactivity Note Proven to react with human.
    Mouse and rat (92% sequence homology).
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_068370
    基因符号
    • hRev
    • EAR1
    • HREV
    • Rev-ErbAalpha
    • Rev-erbA-alpha
    • THRA1
    • THRAL
    • ear-1
    纯化方法 Affinity Purfied
    UniProt编号
    • P20393
    UniProt汇总 FUNCTION: Functions as a constitutive transcriptional repressor. Possible receptor for triiodothyronine.
    SUBUNIT STRUCTURE: Interacts with C1D By similarity.
    SUBCELLULAR LOCATION: Nucleus Potential.
    TISSUE SPECIFICITY: Expressed in all tissues and cell lines examined. Expressed at high levels in some squamous carcinoma cell lines.
    DOMAIN: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.
    SEQUENCE SIMILARITIES: Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in A431 cell lysate.
    Western Blot Analysis: 1 µg/mL of this antibody detected NR1D1 in 10 µg of A431 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8°C for 1 year from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB10130,Anti-NR1D1 (Rev-ErbA α) Antibody

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