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merck millipore,默克密理博,MABF31,Anti-Alpha Defensin-5 (HD5) Antibody, clone 8C8
产品名称：Anti-Alpha Defensin-5 (HD5) Antibody, clone 8C8
产品型号：MABF31
Anti-Alpha Defensin-5 (HD5) Antibody, clone 8C8 detects level of Alpha Defensin-5 (HD5) & has been published & validated for use in IH & WB.
merck millipore,默克密理博,MABF31,Anti-Alpha Defensin-5 (HD5) Antibody, clone 8C8
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB, IHC M Purified Monoclonal Antibody 描述 产品目录编号 MABF31 描述 Anti-Alpha Defensin-5 (HD5) Antibody, clone 8C8 Alternate Names - Defensin, alpha 5
- defensin, alpha 5, Paneth cell-specific
- defensin, alpha 5, preproprotein
- defensin-5
- defensin 5
背景信息 Human alpha defensin-5 (HD5) is one of six peptides belonging to the alpha defensin family. Defensins are small peptides involved in immunological defense against viral and microbial infections through either direct interaction with pathogens or in combination with other immune system factors. There are three subfamilies of defensins (α, β, and θ). α defensins are only observed in mammals and are mainly β-sheet structures. Alpha defensin-5 (HD5) is primarily expressed in the Paneth cells found within the small intestine, and has been shown to possess activity against both Gram-positive and Gram-negative microbes. Studies have shown alpha defensin-5 (HD5) to be a strong antagonist towards human Papillomavirus infection. It may also play a role Crohn’s disease. 产品信息 格式 Purified 控制 - Normal human tranverse colon tissue
演示 Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Alpha Defensin-5 (HD5) Antibody, clone 8C8 detects level of Alpha Defensin-5 (HD5) & has been published & validated for use in IH & WB. 主要应用 - Western Blotting
- Immunohistochemistry
应用说明 Western Blot Analysis: 0.5 ug/mL from a previous lot detected alpha defensin-5 (HD5) in human small intestine tissue lysate. The urea-treated method is recommended instead of SDS page (Shen, B. et al., 2005). 生物信息 免疫原品种 Recombinant protein corresponding to human alpha defensin-5 (HD5). 克隆 8C8 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG2bκ 品种反应性 Human Species Reactivity Note Demonstrated to react with human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_066290
Entrez基因汇总 Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum. [provided by RefSeq]. 基因符号 - HD-5
- DEF5
- DEFA5
纯化方法 Protein G Purified UniProt编号 - Q01523
UniProt汇总 FUNCTION: Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.
SUBUNIT STRUCTURE: Homodimer.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICTY: Paneth cells of the small intestine.
SEQUENCE SIMILARITIES: Belongs to the alpha-defensin family.产品使用声明 质量保证 Evaluated by Immunohistochemistry in normal human tranverse colon tissue.
Immunohistochemistry Analysis: A 1:200 dilution of this antibody detected alpha defensin-5 (HD5) in normal human tranverse colon tissue.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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