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- 体外诊断/OEM材料和试剂
- 产品介绍
描述 产品目录编号 MAB324-K 品牌系列 Chemicon®
商名 - Chemicon
描述 Mouse Anti-Neuron Specific Enolase, clone 5E2 (1mg) 概述 This product is intended for use by IVD manufacturers. Alternate Names - NSE
产品信息 格式 Purified 演示 Liquid in PBS pH 7.4 containing 0.1% sodium azide. 应用 主要应用 - Immunocytochemistry
- ELISA
- Western Blotting
应用说明 Immunoblotting
ELISA
Immunohistochemistry. May be used on formalin-fixed, paraffin embedded sections.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Neuron-specific enolase from human brain. 克隆 5E2 浓缩 1 mg/mL 宿主 Mouse 特异性 Human gamma neuron specific enolase. Recognizes a 45kD band corresponding to gamma NSE on immunoblots of human brain extracts. 同种型 IgG2a 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_001975.2
Entrez基因汇总 This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. 基因符号 - EC 4.2.1.11
- ENO2
- NSE
- Gamma-enolase
UniProt编号 - P09104
UniProt汇总 FUNCTION: SwissProt: P09104 # Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity).
COFACTOR: Magnesium. Required for catalysis and for stabilizing the dimer.
SIZE: 434 amino acids; 47269 Da
SUBUNIT: Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or heterodimers which are cell-type and development-specific.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form (By similarity).
TISSUE SPECIFICITY: The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.DEVELOPMENTAL STAGE: During ontogenesis, there is a transition from the alpha/alpha homodimer to the alpha/beta heterodimer in striated muscle cells, and to the alpha/gamma heterodimer in nerve cells.
SIMILARITY: SwissProt: P09104 ## Belongs to the enolase family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8 °C for up to 12 months under sterile conditions. 包装信息 数量 Bulk packaging. Please inquire.
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