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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Serum Polyclonal Antibody 描述 产品目录编号 AB10081 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-CYP2D6 Antibody Alternate Names - Cytochrome P450 2D6
背景信息 Cytochrome P450 2D6 (CYP2D6), a member of the cytochrome P450 mixed-function oxidase system, is one of the most important enzymes involved in the metabolism of xenobiotics in the body. Whilst CYP2D6 is involved in the oxidation of a wide range of substrates of all the CYPs, there is considerable variability in its expression in the liver. 产品信息 格式 Serum 演示 Raw rabbit serum with 0.1% sodium azide. 应用 应用 Anti-CYP2D6 Antibody detects level of CYP2D6 & has been published & validated for use in WB. 主要应用 - Western Blotting
应用说明 Suggested dilutions:
Western Blot: 1:5000生物信息 免疫原品种 Recombinant human CYP2D6 宿主 Rabbit 同种型 IgG2b 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001025161.1
- NM_000106.4
Entrez基因汇总 This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. 基因符号 - CYP2D@
- CYP2D6
- P450C2D
- MGC120389
- CPD6
- P450-DB1
- CYPIID6
- MGC120390
- CYP2D
- CYP2DL1
UniProt编号 - P10635
UniProt汇总 FUNCTION: SwissProt: P10635 # Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
SIZE: 497 amino acids; 55769 Da
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
SIMILARITY: SwissProt: P10635 ## Belongs to the cytochrome P450 family.产品使用声明 质量保证 Routinely evaluated by immunoblot. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C for up to 12 months from date of receipt. 包装信息 数量 50 µL
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下一件merck millipore产品：merck millipore,默克密理博,219399,Cathepsin D Substrate I - Calbiochem
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