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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB M Purified Monoclonal Antibody 描述 产品目录编号 05-486 Replaces 04-1113 品牌系列 Upstate
商名 - Upstate
描述 Anti-FADD Antibody, clone 1F7 产品信息 格式 Purified 演示 PBS, pH 7.2 and 50% glycerol 应用 应用 Anti-FADD Antibody, clone 1F7 detects level of FADD & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 GST-tagged full-length fusion protein corresponding to human FADD 克隆 clone 1F7 宿主 Mouse 特异性 FADD 同种型 IgG1 品种反应性 MouseHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_003824
Entrez基因汇总 The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. 基因符号 - MORT1
- FADD
- GIG3
- MGC8528
纯化方法 Protein A chromatography UniProt编号 - Q13158
UniProt汇总 FUNCTION: SwissProt: Q13158 # Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis.
SIZE: 208 amino acids; 23279 Da
SUBUNIT: Interacts with CFLAR, PEA15 and MBD4. When phosphorylated, part of a complex containing HIPK3 and FAS. May interact with MAVS/IPS1. Interacts with MOCV v-CFLAR protein and LRDD.
TISSUE SPECIFICITY: Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
DOMAIN:SwissProt: Q13158 Contains a death domain involved in the binding of the corresponding domain within Fas receptor.
PTM: Phosphorylated.
SIMILARITY: Contains 1 death domain. & Contains 1 DED (death effector) domain.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from Jurkat cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,401108,Human IgM, Myeloma
下一件merck millipore产品：merck millipore,默克密理博,17-344,H2A.X Phosphorylation Assay Kit (Flow Cytometry)
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