merck millipore,默克密理博,530007,Prionogenesis inhibitor, DAPH-12 - CAS 145915-63-5

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

merck millipore,默克密理博,530007,Prionogenesis inhibitor, DAPH-12 - CAS 145915-63-5 - Calbiochem

经验配方	CAS号
C₂₂H₁₉N₃O₄	145915-63-5

描述
概述	A cell-permeable 4,5-dianilinophthalimide that antagonizes Aβ42 amyloidogenesis as well as yeast Sup35 N-terminal domain- (aa 1 -124; NM) mediated prionogenesis by blocking the de novo fibrillization process and disassembling preformed NM fibers. Treatment with DAPH-12 greatly reduces the ratio between prion-harboring ([PSI⁺]) and non-prion-harboring ([psi^-]) yeast populations. DAPH-12 is also shown to effectively convert the [PSI⁺] phenotype into that of [psi^-] in a dose-dependent manner, while exhibiting no activity against [RNQ⁺] prion-containing cells. While DAPH-12 is in general more effective than EGCG (Cat. No. 324880) in antagonizing the various forms of NM prions both in cell-free and cell-based system, these two reagents used in tandem can create a synergistic effect against antiprion activity.
产品目录编号	530007
品牌系列	Calbiochem®
同义词	Aβ42 Amyloidogenesis Inhibitor

参考
参考	Roberts, B.E., et al. 2009. Nat. Chem. Bio. 5, 936. Wang, H., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 7159.

生物信息
纯度	≥95% by HPLC

理化信息
溶解度	DMSO

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+2°C to +8°C
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

merck millipore,默克密理博,530007,Prionogenesis inhibitor, DAPH-12 - CAS 145915-63-5 - Calbiochem

whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech