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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, ELISA, WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB10005 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-SMURF1 Antibody 背景信息 Members of the transforming growth factor-beta (TGFB) family signal through type I and type II serine/threonine-kinase receptors, which in turn activate the SMAD signaling pathway. Bone morphogenetic protein (BMP) receptors target SMAD1, SMAD5, and SMAD8, whereas receptors for activin and TGFB (e.g., ACVR1 and TGFBR1, respectively) target SMAD2 and SMAD3. Phosphorylation of these receptor-regulated SMADs induces their association with the common-partner SMAD, SMAD4. Smurf1, a HECT domain E3 ubiquitin ligase, regulates cell polarity and protrusive activity and is required to maintain the transformed morphology and motility of a tumor cell. Atypical protein kinase C-zeta (PKC2), an effector of the Cdc42/Rac1-PAR6 polarity complex, recruits Smurf1 to cellular protrusions, where it controlled the local level of RhoA. Smurf1 thus links the polarity complex to degradation of RhoA in lamellipodia and filopodia to prevent RhoA signaling during dynamic membrane movements. 产品信息 格式 Purified 应用 应用 Anti-SMURF1 Antibody detects level of SMURF1 & has been published & validated for use in ELISA, WB, IH. 主要应用 - Immunohistochemistry
- ELISA
- Western Blotting
生物信息 免疫原品种 This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from a region of human SMURF1 within aa 726~740. 表位 C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Human SMURF1 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_181349.1
- NM_020429.1
Entrez基因汇总 This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. A similar protein in Xenopus is involved in embryonic pattern formation. Alternative splicing results in multiple transcript variants encoding different isoforms. An additional transcript variant has been identified, but its full length sequence has not been determined. 基因符号 - hSMURF1
- SMURF1
- KIAA1625
UniProt编号 - Q9HCE7
UniProt汇总 FUNCTION: SwissProt: Q9HCE7 # E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with receptor-regulated SMADs specific for the BMP pathway, SMAD1 and SMAD5, in order to trigger their ubiquitination and degradation and hence their inactivation.
SIZE: 757 amino acids; 86114 Da
SIMILARITY: SwissProt: Q9HCE7 ## Contains 1 C2 domain. & Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. & Contains 2 WW domains.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. 包装信息 数量 100 µg
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