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merck millipore,默克密理博,07-564,Anti-acetyl-Histone H2B (Lys120) Antibody
产品名称:Anti-acetyl-Histone H2B (Lys120) Antibody
产品型号:07-564
Use Anti-acetyl-Histone H2B (Lys120) Antibody (Rabbit Polyclonal Antibody) validated in DB, WB, PIA to detect acetyl-Histone H2B (Lys120) also known as H2BK120Ac, Histone H2B (acetyl K120).
merck millipore,默克密理博,07-564,Anti-acetyl-Histone H2B (Lys120) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-564 品牌系列 Upstate
商名 - Upstate
描述 Anti-acetyl-Histone H2B (Lys120) Antibody Alternate Names - Histone H2B (acetyl K120)
- H2BK120Ac
产品信息 格式 Affinity Purified 演示 50mM Tris-glycine, pH 8.0 containing 0.05% sodium azide and 30% glycerol 应用 应用 Use Anti-acetyl-Histone H2B (Lys120) Antibody (Rabbit Polyclonal Antibody) validated in DB, WB, PIA to detect acetyl-Histone H2B (Lys120) also known as H2BK120Ac, Histone H2B (acetyl K120). 主要应用 - Western Blotting
生物信息 免疫原品种 Peptide containing the sequence VTacKYT in which acK corresponds to acetylated lysine 120 of human histone H2B. 宿主 Rabbit 特异性 Histone H2B acetylated on lysine 120 同种型 IgG 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_778225
Entrez基因汇总 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. 基因符号 - HIST3H2BB
修改 - Acetylation
纯化方法 Immunoaffinity purified UniProt编号 - Q8N257
UniProt汇总 FUNCTION: SwissProt: Q8N257 # Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
SIZE: 126 amino acids; 13908 Da
SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
SUBCELLULAR LOCATION: Nucleus.
PTM: Monoubiquitination of Lys-121 by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. & Phosphorylated on Ser-15 by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class- switch recombination.
SIMILARITY: SwissProt: Q8N257 ## Belongs to the histone H2B family.产品使用声明 质量保证 routinely evaluated by immunoblot on acid extracts from sodium butyrate treated HeLa cells. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at -20°C 包装信息 数量 100 µL
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