merck millipore,默克密理愽
  • merck millipore,默克密理博,681660,N-WASP-Inhibitor, 187-1 - Calbiochem

  • merck millipore,默克密理博,681660,N-WASP-Inhibitor, 187-1 - Calbiochem

    产品名称：N-WASP-Inhibitor, 187-1 - Calbiochem
    产品型号：681660
    The N-WASP-Inhibitor, 187-1 controls the biological activity of neural Wiskott Aldrich syndrome protein (N-WASP). This small molecule/inhibitor is primarily used for Cell Structure applications.

    merck millipore,默克密理博,681660,N-WASP-Inhibitor, 187-1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,681660,N-WASP-Inhibitor, 187-1 - Calbiochem

    重要规格表

    经验配方
    C₉₆H₁₂₂N₁₈O₁₆
    描述
    概述 A 14-amino acid cyclic peptide that potently blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-induced actin assembly in Xenopus egg cytoplasmic extract (IC50 ~ 2 µM). Shown to directly bind to neural Wiskott Aldrich syndrome protein (N-WASP) with high-affinity, and prevent the activation of actin-related protein 2/3 (Arp2/3) complex by inhibiting the interaction between N-WASP and Arp2/3.
    产品目录编号 681660
    品牌系列 Calbiochem®
    同义词 cyclo(LKDFDPDFLFDPLQ)₂
    参考
    参考 Peterson, J.R., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10624.
    Suetsugu, S., et al. 2001. J. Biol. Chem. 276, 33175.
    产品信息
    具有ATP竞争性 N
    形式 White lyophilized solid
    配方 Supplied as a trifluoroacetate salt.
    Hill配方 C₉₆H₁₂₂N₁₈O₁₆
    化学配方 C₉₆H₁₂₂N₁₈O₁₆
    Molar Mass 1784.1
    吸湿 Hygroscopic
    肽序列 cyclo(LLys-DPhe-DPro-DPhe-LPhe-DPro-LGln)₂
    可逆 N
    生物信息
    主靶 Neural Wiskott Aldrich syndrome protein (N-WASP)
    主靶IC50 ~ 2 µM blocking phosphatidylinositol 4,5-bisphosphate (PIP2)-induced actin assembly in Xenopus egg cytoplasmic extract
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 N
    溶解度 DMSO or Acetic Acid
    肽序列 cyclo(LLys-DPhe-DPro-DPhe-LPhe-DPro-LGln)₂
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,681660,N-WASP-Inhibitor, 187-1 - Calbiochem

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