merck millipore,默克密理愽
  • merck millipore,默克密理博,MABE416,Anti-Cisplatin DNA Adducts Antibody, clone ICR4

  • merck millipore,默克密理博,MABE416,Anti-Cisplatin DNA Adducts Antibody, clone ICR4

    产品名称：Anti-Cisplatin DNA Adducts Antibody, clone ICR4
    产品型号：MABE416
    Detect Cisplatin adducts using this rat monoclonal antibody, Anti-Cisplatin DNA Adducts Antibody, clone ICR4 validated for use in Dot Blot, ELISA & IHC.

    merck millipore,默克密理博,MABE416,Anti-Cisplatin DNA Adducts Antibody, clone ICR4

  • 产品介绍
  • merck millipore,默克密理博,MABE416,Anti-Cisplatin DNA Adducts Antibody, clone ICR4

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, ELISARPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABE416
    描述 Anti-Cisplatin DNA Adducts Antibody, clone ICR4
    Alternate Names
    • Cisplatin, DNA modification
    • CP9/19
    背景信息 Cisplatin adducts are Guanine-Guanine (GG) DNA intrastrand cross links caused by the chemical compound Cisplatin. Cisplatin is used as a chemotherapy agent that contains platinum. The crosslinking of the DNA triggers apoptosis in the effected cell. Cisplatin is particularly effective in certain cancers such as testicular cancer. Unfortunately like most chemotherapy agents Cisplatin has many side effects and cancer cells typically will develop resistance to the drug after a period of time. Clone ICR4 was formerly known as clone CP9/19.
    产品信息
    格式 Purified
    演示 Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect Cisplatin adducts using this rat monoclonal antibody, Anti-Cisplatin DNA Adducts Antibody, clone ICR4 validated for use in Dot Blot, ELISA & IHC.
    主要应用
    • Immunohistochemistry
    • ELISA
    应用说明 ELISA Analysis: A representative lot from an independent laboratory detected Cisplatin DNA Adducts in ELISA (Tilby, M. J., et al. (1991). Cancer Res. 51(1):123-129.; Kothandapani, A., et al. (2011). J Biol Chem. 286(16):14564-14574.; Welters, M. J., et al. (1999). Ann Oncol. 10(1):97-103.; Strobeck, M. W., et al. (2000). Proc Natl Acad Sci USA. 97(14):7748-7753.; Kothandapani, A., et al. (2012). Exp Cell Res. 18(16):1973-1986.).

    Immunohistochemistry Analysis: A representative lot from an independent laboratory detected Cisplatin DNA Adducts in Head and Neck Squamous Cell Carcinoma tissues. (Welters, M. J., et al. (1999). Ann Oncol. 10(1):97-103.).
    生物信息
    免疫原品种 Cisplatin modified native DNA.
    克隆 1CR4
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rat
    特异性 This antibody demonstrates specificity for cisplatin modified DNA.
    同种型 IgG2aκ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • N/A
    纯化方法 Protein G purified
    UniProt编号
    • NA
    产品使用声明
    质量保证 Evaluated by Dot Blot in untreated and Cisplatin treated DNA from HeLa cell lysates.

    Dot Blot Analysis: A 1:1,000 dilution of this antibody detected Cisplatin DNA Adducts in 1.0 and 0.5 µg of Cisplatin treated DNA from HeLa cell lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABE416,Anti-Cisplatin DNA Adducts Antibody, clone ICR4

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