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merck millipore,默克密理博,23-021M,UBE1 Protein, active, 250 µg
产品名称：UBE1 Protein, active, 250 µg
产品型号：23-021M
Active, full length, recombinant human UBE1. N-terminal 6His-tagged. For use in Enzyme Assays. Functions as an E1 enzyme in ubiquitination assays.
merck millipore,默克密理博,23-021M,UBE1 Protein, active, 250 µg
- 产品介绍
重要规格表
主要应用 品种 级联部件 EA Human E1 描述 产品目录编号 23-021M 品牌系列 Upstate
商名 - Upstate
描述 UBE1 Protein, active, 250 µg 长描述 N-terminal 6His-tagged, recombinant human UBE1 full length, expressed by baculovirus in Sf21 insect cells. Alternate Names - A1S9 Protein
- Ubiquitin activating enzyme E1
- Ubiquitin-like modifier-activating enzyme 1
- UBA1
背景信息 UBE1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. It is responsible for the primary ubiquitin-protein isopeptide bond formation and is a critical component for the initiation of in vitro conjugation reactions. UBE1 activates ubiquitin by the ATP dependent adenylation of its C-terminal glycine carboxyl group. This ubiquitin residue is then linked to the sulphydryl side chain moiety of a cysteine residue within UBE1 by forming a high energy thiol ester bond, liberating free AMP. There are two active sites within the UBE1 molecule allowing it to accommodate two ubiquitin molecules at one time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site. The activated ubiquitin is then transferred to the lysine of target proteins via the E2/E3 conjugation cascade. 应用 应用 Active, full length, recombinant human UBE1. N-terminal 6His-tagged. For use in Enzyme Assays. Functions as an E1 enzyme in ubiquitination assays. 主要应用 - Enzyme Assay
生物信息 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. 级联部件 E1 Entrez基因编号 - NM_003334 (GenBank Number)
纯化方法 Purified using immobilized metal affinity chromatography. 产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
包装信息 数量 250 µg
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