merck millipore,默克密理愽
  • merck millipore,默克密理博,676500,VEGFR2/Flt3/c-Kit Inhibitor - CAS 796967-10-7 - Calbiochem

  • merck millipore,默克密理博,676500,VEGFR2/Flt3/c-Kit Inhibitor - CAS 796967-10-7 - Calbiochem

    产品名称：VEGFR2/Flt3/c-Kit Inhibitor - CAS 796967-10-7 - Calbiochem
    产品型号：676500
    The VEGFR2/Flt3/c-Kit Inhibitor, also referenced under CAS 796967-10-7, controls the biological activity of VEGFR2/Flt3/c-Kit. This small molecule/inhibitor is primarily used for Activators/Inducers a More>>

    merck millipore,默克密理博,676500,VEGFR2/Flt3/c-Kit Inhibitor - CAS 796967-10-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,676500,VEGFR2/Flt3/c-Kit Inhibitor - CAS 796967-10-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₁H₁₉N₅O796967-10-7
    描述
    概述 A cell-permeable 3-aminoindazolylurea compound that acts as a potent and ATP-competitive inhibitor of VEGFR2/KDR (IC50 = 3 nM) as well as Flt3 and cKit (IC50 = 4 to 20 nM). Shown to block VEGF-induced VEGFR2 phosphorylation in 3T3-murine fibroblasts in vitro (IC50 = 13 nM) and exhibit oral availability (AUC = 6.5 µM•h with an oral dose of 10 mg/kg in CD-1 mice) and in vivo efficacy in a murine estradiol-induced uterine edema model (ED50 = 4 mg/kg p.o. in balb/c mice).
    产品目录编号 676500
    品牌系列 Calbiochem®
    同义词 N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-Nʹ-(3-methylphenyl)urea, Vascular Endothelial Growth Factor Receptor-2/Flt3/c-Kit Inhibitor, VEGFR Tyrosine Kinase Inhibitor XXV, VEGFR2 Kinase Inhibitor XXII, Flt-3 Inhibitor V, c-Kit Inhibitor I
    参考
    参考 Dai, Y., et al. 2007. J. Med. Chem. 50, 1584.
    产品信息
    CAS号 796967-10-7
    形式 Off-white solid
    Hill配方 C₂₁H₁₉N₅O
    化学配方 C₂₁H₁₉N₅O
    Molar Mass 357.4
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,676500,VEGFR2/Flt3/c-Kit Inhibitor - CAS 796967-10-7 - Calbiochem

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