merck millipore,默克密理愽
  • merck millipore,默克密理博,09-822,Anti-KLF5 (Krüppel-like factor 5) Antibody

  • merck millipore,默克密理博,09-822,Anti-KLF5 (Krüppel-like factor 5) Antibody

    产品名称：Anti-KLF5 (Krüppel-like factor 5) Antibody
    产品型号：09-822
    Anti-KLF5 (Krüppel-like factor 5) Antibody is a Rabbit Polyclonal Antibody for detection of KLF5 (Krüppel-like factor 5) also known as Krüppel-like factor 5 & has been validated in WB.

    merck millipore,默克密理博,09-822,Anti-KLF5 (Krüppel-like factor 5) Antibody

  • 产品介绍
  • merck millipore,默克密理博,09-822,Anti-KLF5 (Krüppel-like factor 5) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MChIP, WBRbSerumPolyclonal Antibody
    描述
    产品目录编号 09-822
    描述 Anti-KLF5 (Krüppel-like factor 5) Antibody
    Alternate Names
    • intestinal-enriched kruppel-like factor
    • BTE-binding protein 2
    • Basic transcription element-binding protein 2
    • Colon krueppel-like factor
    • GC box binding protein 2
    • GC-box-binding protein 2
    • Intestinal-enriched krueppel-like factor
    • Kruppel-like factor 5
    • Kruppel-like factor 5 (intestinal)
    • Transcription factor BTEB2
    • basic transcription element binding protein 2
    • colon kruppel-like factor
    背景信息 Krüppel-like factors (KLFs) are zinc finger-containing transcription factors with regulatory functions in cell growth, proliferation, differentiation, and embryogenesis. KLF5, (also known as BTEB2 and IKLF), is essential for mouse embryo development. KLF5 activates many genes during cardiovascular remodeling, including PDGFa/b, Egr-1, PAI-1, iNOS, and VEGF receptors, making KLF a potential therapeutic target for cardiovascular disease. KLF5 also plays a role in angiogenesis and in development of several tumor types including breast, prostate, bladder, colon, esophagus, and skin. KLF5 is closely related to other of the KLF family members. However, KLF5 and KLF4 exhibit opposite effects on regulation of gene transcription, despite binding to similar, if not identical, cis-acting DNA sequences. In addition, KLF4 and 5 exert contrasting effects on cell proliferation in many instances; while KLF4 is an inhibitor of cell growth, KLF5 stimulates proliferation.
    产品信息
    格式 Serum
    控制
    • Mouse embryonic stem cell chromatin extract
    演示 Rabbit polyclonal serum containing 0.05% sodium azide.
    应用
    应用 Anti-KLF5 (Krüppel-like factor 5) Antibody is a Rabbit Polyclonal Antibody for detection of KLF5 (Krüppel-like factor 5) also known as Krüppel-like factor 5 & has been validated in WB.
    主要应用
    • Chromatin Immunoprecipitation (ChIP)
    • Western Blotting
    应用说明 Chromatin Immunoprecipitation Analysis (ChIP):
    A representative lot was used by an independent laboratory in ChIP. (Ng Huck Hui, Genome Institute of Singapore)
    生物信息
    免疫原品种 Recombinant protein corresponding to mouse Krüppel-like factor 5 at the N-terminus.
    表位 N-terminus
    宿主 Rabbit
    特异性 This antibody recognizes Krüppel-like factor 5 at the N-terminus.
    品种反应性 Mouse
    Species Reactivity Note Demonstrated to react with mouse.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_033899
    基因符号
    • IKLF
    • KLF5
    • CKLF
    • BTEB2
    纯化方法 Unpurified
    UniProt编号
    • Q9Z0Z7
    UniProt汇总 FUNCTION: Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

    SUBUNIT STRUCTURE: Interacts with WWP1 (By similarity).

    SUBCELLULAR LOCATION: Nucleus.

    TISSUE SPECIFICTY: Highest expression in digestive track.

    PTM: Ubiquitinated (By similarity). Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.

    SEQUENCE SIMILARITIES: Belongs to the krueppel C2H2-type zinc-finger protein family.

    Contains 3 C2H2-type zinc fingers.
    产品使用声明
    质量保证 Evaluated by Western Blot in mouse embryonic stem cell chromatin extract.

    Western Blot Analysis: 1:2,000 dilution of this antibody detected Krüppel-like factor 5 on 10 µg of mouse embryonic stem cell chromatin extract.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,09-822,Anti-KLF5 (Krüppel-like factor 5) Antibody

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