merck millipore,默克密理愽
  • merck millipore,默克密理博,05-1520,Anti-HnRNP C1/C2 Antibody, clone 4F4

  • merck millipore,默克密理博,05-1520,Anti-HnRNP C1/C2 Antibody, clone 4F4

    产品名称：Anti-HnRNP C1/C2 Antibody, clone 4F4
    产品型号：05-1520
    Anti-HnRNP C1/C2 Antibody, clone 4F4 is a Mouse Monoclonal Antibody for detection of HnRNP C1/C2 also known as heterogeneous nuclear ribonucleoprotein C (C1/C2) & has been validated in WB.

    merck millipore,默克密理博,05-1520,Anti-HnRNP C1/C2 Antibody, clone 4F4

  • 产品介绍
  • merck millipore,默克密理博,05-1520,Anti-HnRNP C1/C2 Antibody, clone 4F4

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-1520
    描述 Anti-HnRNP C1/C2 Antibody, clone 4F4
    Alternate Names
    • nuclear ribonucleoprotein particle C2 protein
    • heterogeneous nuclear ribonucleoprotein C
    • heterogeneous nuclear ribonucleoprotein C (C1/C2)
    • hnRNP C1 / hnRNP C2
    • nuclear ribonucleoprotein particle C1 protein
    背景信息 The hnRNP C proteins (C1/C2) are nuclear pre-mRNA-binding proteins that belong to the large RNP motif family of RNA-binding proteins. The proteins encoded by this gene act as a tetramer and are involved in the assembly of 40S hnRNP particles. The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins aassociate with pre-mRNAs in the nucleus and influence pre-mRNA processing and other aspects of mRNA metabolism and transport. In vivo, hnRNP C proteins have been found to interact with Grb2.
    产品信息
    格式 Purified
    控制
    • HeLa nuclear extract lysate
    演示 Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide
    应用
    应用 Anti-HnRNP C1/C2 Antibody, clone 4F4 is a Mouse Monoclonal Antibody for detection of HnRNP C1/C2 also known as heterogeneous nuclear ribonucleoprotein C (C1/C2) & has been validated in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 RNP’s eluted from oligo (dT) cellulose column of human HnRNP C1/C2.
    表位 Unknown
    克隆 4F4
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes HnRNP C1/C2.
    同种型 IgG2bκ
    品种反应性 MouseHuman
    Species Reactivity Note Demonstrated to react with human. Predicted to react with mouse based on 100% sequence homology.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001070910.1
    Entrez基因汇总 This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq].
    基因符号
    • hnRNPC
    • HNRNPC
    • C1
    • C2
    • HNRNP
    • HNRPC
    • SNRPC
    纯化方法 Protein G purfied
    UniProt编号
    • P07910
    UniProt汇总 FUNCTION: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules.

    SUBUNIT STRUCTURE: Tetramer composed of 3 copies of isoform C1 and 1 copy of isoform C2. Assembly of 3 tetramers with bound pre-mRNA gives rise to a 19S complex that interacts with HNRNPA2B1 tetramers. Component of the 40S hnRNP particle. Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRNPA1, HNRNPA2B1, HNRPA3, HNRNPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRNPR, HNRNPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8. Interacts with IGF2BP1.

    SUBCELLULAR LOCATION: Nucleus. Note: Component of ribonucleosomes.

    PTM: Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide.

    Sumoylated. Sumoylation reduces affinity for mRNA.

    SEQUENCE SIMILARITIES: Belongs to the RRM HNRPC family. RALY subfamily.

    Contains 1 RRM (RNA recognition motif) domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in HeLa nuclear extract lysate.

    Western Blot Analysis: 0.01 µg/ml of this antibody detected HnRNP C1/C2 on 10 µg of HeLa nuclear extract lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-1520,Anti-HnRNP C1/C2 Antibody, clone 4F4

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