- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,676496,VEGF Inhibitor, CBO-P11 - Calbiochem
产品名称：VEGF Inhibitor, CBO-P11 - Calbiochem
产品型号：676496
The VEGF Inhibitor, CBO-P11 controls the biological activity of VEGF. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
merck millipore,默克密理博,676496,VEGF Inhibitor, CBO-P11 - Calbiochem
- 产品介绍
重要规格表
经验配方 C₉₀H₁₄₀N₂₈O₂₂S 描述 概述 A macrocyclic 17-amino acid peptide derived from residues 79 - 93 of vascular endothelial growth factor that mediate its binding to VEGFR-2. It blocks the binding of VEGF165 to its receptors (IC50 = 700 nM for VEGFR1, 1.3 µM for VEGFR2) and exhibits anti-angiogenic activity as well as other VEGFR-mediated cellular functions, such as proliferation (IC50 = 5.8 µM), migration (IC50 = 8.2 µM), and activation of MAP kinases. Its anti-angiogenic activity has been successfully demonstrated in vivo using chick embryos and nude mice tumor models of human intracranial and syngeneic glioma. 产品目录编号 676496 品牌系列 Calbiochem®
同义词 Cyclo-VEGI, cyclic(D-F-PQIMRIKPHQGQHIGE), D-Phe-Pro(79-93), VEGFR Tyrosine Kinase Inhibitor XX, VEGFR2 Kinase Inhibitor XVI 参考 参考 Zilberberg, L., et al. 2003. J. Biol. Chem. 278, 35564. 产品信息 具有ATP竞争性 N 形式 White lyophilized solid 配方 Supplied as a trifluoroacetate salt. Hill配方 C₉₀H₁₄₀N₂₈O₂₂S 化学配方 C₉₀H₁₄₀N₂₈O₂₂S Molar Mass 1998.3 吸湿 Hygroscopic
肽序列 cyclic(D-Phe-Pro-Gln-Ile-Met-Arg-Ile-Lys-Pro-His-Gln-Gly-Gln-His-Ile-Gly-Glu) 可逆 N 生物信息 主靶 Blocks the binding of VEGF165 to its receptors 主靶IC50 700 nM for VEGFR1, 1.3 µM for VEGFR2 纯度 ≥97% by HPLC 理化信息 细胞可渗透 N 溶解度 DMSO or H₂O 肽序列 cyclic(D-Phe-Pro-Gln-Ile-Met-Arg-Ile-Lys-Pro-His-Gln-Gly-Gln-His-Ile-Gly-Glu) 储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Carcinogenic / Teratogenic
储存 -20°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,MABC306,Anti-phospho-ULK1 (Ser638) Antibody, clone 6B3.2
下一件merck millipore产品：merck millipore,默克密理博,MABD65,Anti-Pax3 Antibody, clone 1A7.1
相关产品
merck millipore,默克密理博,14-251M,p38α/SAPK2a Protein, active, 250 µg
merck millipore,默克密理博,ABE73,Anti-FoxP2 Antibody
merck millipore,默克密理博,SF-199,RPLP0; Mouse, Cyanine 5, RNA Detection Probe,SmartFlare
merck millipore,默克密理博,MABC306,Anti-phospho-ULK1 (Ser638) Antibody, clone 6B3.2
merck millipore,默克密理博,MABD65,Anti-Pax3 Antibody, clone 1A7.1
merck millipore,默克密理博,SVGVL10RC,Sterivex-GV，0.22 µm，PVDF，带 Luer 出口，射线灭菌
merck millipore,默克密理博,ABC414,Anti-WWP2 Antibody
merck millipore,默克密理博,AG240,Synuclein α, control peptide for AB5334P
merck millipore,默克密理博,MAB3222,Anti-BrdU Antibody, clone IIB5