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merck millipore,默克密理博,MABC306,Anti-phospho-ULK1 (Ser638) Antibody, clone 6B3.2
产品名称：Anti-phospho-ULK1 (Ser638) Antibody, clone 6B3.2
产品型号：MABC306
This Anti-phospho-ULK1 (Ser638) Antibody, clone 6B3.2 is validated for use in Western Blotting and Immunocytochemistry for the detection of phospho-ULK1 (Ser638).
merck millipore,默克密理博,MABC306,Anti-phospho-ULK1 (Ser638) Antibody, clone 6B3.2
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H ICC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MABC306 描述 Anti-phospho-ULK1 (Ser638) Antibody, clone 6B3.2 Alternate Names - Unc-51-like kinase 1
- ULK1
- Serine/threonine-protein kinase ULK1
- Autophagy-related protein 1 homolog
- ATG1
- hATG1
背景信息 ULK1 or autophagy-related protein 1 homolog (ATG1) is a serine/threonine protein kinase. It is a ubiquitously expressed protein that is highly abundant in the brain, skeletal muscle, and heart. It is involved in the signaling pathway of mTOR receptors leading to the regulation of autophagy in nutrient-deprived cells. mTOR may interact with ULK1 as a complex of ULK1/FIP200/Atg13. Phosphorylation of ULK1 at Ser638 is mediated by mTOR, which is a regulator of cell growth and an inhibitor of autophagy that disrupts the interaction between ULK1 and AMPK. ULK1 may play an important role in neuronal development: Elimination of ULK1's enzymatic activity by targeted disruption of its kinase domain has blocked the outgrowth of neurons in the developing mouse brain, possibly by blocking the ULK1-mediated trafficking of neurotrophins. 产品信息 格式 Purified 演示 Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. 应用 应用 This Anti-phospho-ULK1 (Ser638) Antibody, clone 6B3.2 is validated for use in Western Blotting and Immunocytochemistry for the detection of phospho-ULK1 (Ser638). 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunocytochemistry Analysis: A 1:50 dilution of this antibody detected phospho-ULK1 (Ser638) in Serum-starved A431 cells. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to Human phospho-ULK1 (Ser638). 克隆 6B3.2 浓缩 0.5 mg/mL 宿主 Mouse 特异性 This antibody detects ULK1 phosphorylated at Ser638. 同种型 IgMκ 品种反应性 Human Species Reactivity Note Human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_003556
基因符号 - KIAA0722
- ULK1
纯化方法 Purified by ion-exchange chromatography UniProt编号 - O75385
产品使用声明 质量保证 Evaluated by Western Blotting in MCF-7 cell lysate -/+ Lambda Phosphatase.
Western Blotting Analysis: 1 µg/mL of this antibody detected phospho-ULK1 (Ser638) in 200 µg of MCF-7 cell lysate -/+ Lambda Phosphatase.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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