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merck millipore,默克密理博,ABE73,Anti-FoxP2 Antibody
产品名称：Anti-FoxP2 Antibody
产品型号：ABE73
Anti-FoxP2 Antibody is a Rabbit Polyclonal Antibody for detection of FoxP2 also known as forkhead box P2, trinucleotide repeat containing 10 & has been validated in WB & IHC.
merck millipore,默克密理博,ABE73,Anti-FoxP2 Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H, M, Rb IHC, WB Rb Serum Polyclonal Antibody 描述 产品目录编号 ABE73 描述 Anti-FoxP2 Antibody Alternate Names - speech and language disorder 1
- forkhead box P2
- trinucleotide repeat containing 10
- CAG repeat protein 44
- forkhead/winged-helix transcription factor
- Trinucleotide repeat-containing gene 10 protein
背景信息 Forkhead box protein P2 (FoxP2) is a multidomain transcriptional repressor that belongs to the Fox family of proteins. The FoxP2 protein contains a forkhead-box DNA-binding domain, characteristic of the FOX group of transcription factors. In addition, this protein contains a polyglutamine tract, as well as zinc finger and leucine zipper motifs. In order for FoxP2 to bind DNA, it forms homodimers and heterodimers with FoxP1 and FoxP4.
The forkhead box family of proteins play an important role in immune response, organ development and the development of cancer. Functional studies in vertebrates suggest this with this gene plays a role in the modulation neural plasticity. In line with these findings, mutations of FoxP2 in humans have been linked to speech and language disorders.产品信息 格式 Serum 控制 - RAW264.7 cell lysate
演示 Unpurified rabbit polyclonal serum with 0.05% sodium azide. 应用 应用 Anti-FoxP2 Antibody is a Rabbit Polyclonal Antibody for detection of FoxP2 also known as forkhead box P2, trinucleotide repeat containing 10 & has been validated in WB & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Western Blot Analysis: 1:1,000 dilution from a representative lot detected FoxP2 in 10 µg of L6, NIH/3T3, mouse brain, rat brain, and human brain lysates.
Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in IH. (Lu, M.M., et al. (2002). Mechanisms of Development 119S:S197–S202.)生物信息 免疫原品种 GST-tagged recombinant protein corresponding to mouse FoxP2. 表位 Unknown 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes FoxP2. 同种型 IgG 品种反应性 HumanMouseRabbit Species Reactivity Note Demonstrated to react with human, mouse, and rabbit. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_444472
基因符号 - SPCH1
- CAGH44
- TNRC10
纯化方法 Unpurified UniProt编号 - P58463
UniProt汇总 FUNCTION: Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential.
SUBUNIT STRUCTURE: Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1.
SUBCELLULAR LOCATION: Nucleus Probable.
TISSUE SPECIFICITY: Highest expression in lung. Lower expression in spleen, skeletal muscle, brain, kidney and small intestine.
DEVELOPMENTAL STAGE: Expressed in developing lung, neural, intestinal and cardiovascular tissues. Expressed at a high level in the distal airway epithelium and at a low level in the proximal airway epithelium at 12.5 dpc, and restricted to the distal airway epithelium by 14.5 dpc. In the spinal cord, at 12.5 dpc, expressed in a subset of interneurons dorsal to motor neurons. At 16.5 dpc, expression in the brain is observed in the inner intermediate zone of the neopallial cortex and in the developing cerebral hemispheres. In the gastrointestinal system, at 12.5 expressed in the outer mesodermal layer and in the intestinal epithelium. By 16.5 dpc, expression is restricted to the outer longitudinal muscle layer of the intestine and stomach. In the cardiovascular system, at 14.5 dpc, expressed in the outflow tract region of the developing heart. By 16.5 dpc, observed in the outflow tract and atrium, but not in the ventricles.
DOMAIN: The leucine-zipper is required for dimerization and transcriptional repression.
SEQUENCE SIMILARITIES: Contains 1 C2H2-type zinc finger.
Contains 1 fork-head DNA-binding domain.产品使用声明 质量保证 Evaluated by Western Blot in RAW264.7 cell lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected FoxP2 on 10 µg of RAW264.7 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,14-251M,p38α/SAPK2a Protein, active, 250 µg
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