merck millipore,默克密理愽
  • merck millipore,默克密理博,662142,DUB Inhibitor VI, P22077 - Calbiochem

  • merck millipore,默克密理博,662142,DUB Inhibitor VI, P22077 - Calbiochem

    产品名称：DUB Inhibitor VI, P22077 - Calbiochem
    产品型号：662142
    The DUB Inhibitor VI, P22077 controls the biological activity of DUB. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

    merck millipore,默克密理博,662142,DUB Inhibitor VI, P22077 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,662142,DUB Inhibitor VI, P22077 - Calbiochem

    重要规格表

    经验配方
    C₁₂H₇F₂NO₃S₂
    描述
    概述 A cell-permeable thiophenylethanone that is shown to inhibit USP7 and USP47 deubiquitinase activity (IC50 = 8.01 & 8.74 µM, respectively), while exhibiting much reduced affinity toward ATXN3, BAP1, and USP1, and displaying no inhibitory activity toward other known PR-619 (Cat. No. 662141) targets (IC50 >50 µM). Both P22077 and PR-619 are shown to increase overall protein polyubiquitination in HEK293T cells in a dose- and time-dependent manner (20 to 150 µM; 0.5 to 20 h), however PR619 treatment results in upregulation of both K48- and K63-linked, while P22077 exposure results in mainly enrichment of K48-linked polyUb chains.
    产品目录编号 662142
    品牌系列 Calbiochem®
    同义词 P022077, 1-(5-(2,4-Difluorophenylthio)-4-nitrothiophen-2-yl)ethanone, USP7 Inhibitor II, USP47 Inhibitor II
    参考
    参考 Altun, M., et al. 2011. Chem. Biol. 18, 1401.
    Tian, X., et al. 2011. Assay Drug Dev. Technol. 9, 165.
    产品信息
    形式 Off-white solid
    Hill配方 C₁₂H₇F₂NO₃S₂
    化学配方 C₁₂H₇F₂NO₃S₂
    Molar Mass 315.3
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,662142,DUB Inhibitor VI, P22077 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,14-501,JNK3/SAPK1b Protein, active, 10 µg
下一件merck millipore产品：merck millipore,默克密理博,481971,NADP, Monosodium Salt - CAS 1184-16-3 - Calbiochem


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