merck millipore,默克密理愽
  • merck millipore,默克密理博,647925,Trichostatin A, Streptomyces sp. - CAS 58880-19-6 - Calbiochem

  • merck millipore,默克密理博,647925,Trichostatin A, Streptomyces sp. - CAS 58880-19-6 - Calbiochem

    产品名称：Trichostatin A, Streptomyces sp. - CAS 58880-19-6 - Calbiochem
    产品型号：647925
    A potent and reversible, cell-permeable inhibitor of histone deacetylase.

    merck millipore,默克密理博,647925,Trichostatin A, Streptomyces sp. - CAS 58880-19-6 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,647925,Trichostatin A, Streptomyces sp. - CAS 58880-19-6 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₇H₂₂N₂O₃58880-19-6
    描述
    概述 A potent and reversible, cell-permeable inhibitor of histone deacetylase. Blocks cell cycle progression at the G1 phase in HeLa cells and induces a 12-fold increase in intracellular levels of gelsolin. Induces reversion of oncogenic ras-transformed NIH/3T3 cells to a normal morphology. Inhibits IL-2 gene expression (IC50 = 73 nM) in Jurkat cells and shows immunosuppressive activity in a mouse model. Down-regulates p57kip2 in Hep 3B cells. A 10 mM (500 µg/165 µl) solution of Trichostatin A, Streptomyces sp. (Cat. No. 647926) in DMSO is also available.
    产品目录编号 647925
    品牌系列 Calbiochem®
    同义词 4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, TSA, HDAC Inhibitor IX
    参考
    参考 Gray, S.G. and Ekstrom, T.J. 1998. Biochem. Biophys. Res. Commun. 245, 423.
    Takahashi, I., et al. 1996. J. Antibiot. 49, 453.
    Taunton, J., et al. 1996. Science 272, 408.
    Futamura, M., et al. 1995. Oncogene 10, 1119.
    Hoshikawa, Y., et al. 1994. Exp. Cell Res. 214, 189.
    产品信息
    CAS号 58880-19-6
    具有ATP竞争性 N
    形式 Off-white lyophilized solid
    Hill配方 C₁₇H₂₂N₂O₃
    化学配方 C₁₇H₂₂N₂O₃
    Molar Mass 302.4
    可逆 Y
    结构配方图像
    生物信息
    主靶 histone deactylase
    主靶IC50 73 nM inhibiting IL-2 gene expressionin Jurkat cells
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO, EtOH, MeOH
    GHS安全信息
    RTECS MI5215000
    安全信息
    R相 R: 20/21/22-36/37/38-43

    Harmful by inhalation, in contact with skin and if swallowed.
    Irritating to eyes, respiratory system and skin.
    May cause sensitization by skin contact.
    S相 S: 26-36

    In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    Wear suitable protective clothing.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Harmful
    储存 -20°C
    无需冷冻 No
    特殊指南 Following reconstitution in DMSO, aliquot and freeze (-20°C). Following reconstitution in ethanol, refrigerate (4°C). DMSO stock solutions are stable for up to 6 months at -20°C. Ethanol stock solutions are stable for up to 3 months at 4°C.

    merck millipore,默克密理博,647925,Trichostatin A, Streptomyces sp. - CAS 58880-19-6 - Calbiochem

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