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- 体外诊断/OEM材料和试剂
- 产品介绍
描述 产品目录编号 CBL582-MG-KC 品牌系列 Chemicon®
商名 - Chemicon
描述 Mouse Anti-Human CD19, clone HD37 (1mg) KC 概述 This product is intended for use by IVD manufacturers. Alternate Names - B-lymphocyte Surface Antigen B4
产品信息 格式 Purified 演示 The monoclonal is presented at a concentration of 100μg/1ml in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application. 应用 主要应用 - Immunohistochemistry
- Flow Cytometry
应用说明 Identification of CD19 positive B lymphocytes and malignant B cells by indirect immunofluorescence staining
Leukaemia and lymphoma phenotyping
Identification of normal and malignant CD19 positive B lymphocytes in cryostat frozen sections
Immunoprecipitation of the CD19 antigen
Studies of the CD19/21 complex in B cell activation and the control of B cell development
Optimal working dilutions must be determined by the end user.生物信息 克隆 HD37 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 The CD19 antigen (90 kDa) is expressed from the earliest stages of B-progenitor development, on all peripheral B cells including germinal centre B cells and all B cell lines and B cell leukaemias tested. T cell and monocytic cell lines are negative and the antigen is lost on B cell maturations to plasma cells. The antigen is a type I integral membrane glycoprotein whose in vitro inhibition will influence B cell activation and proliferation. 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_001770.4
Entrez基因汇总 Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. 基因符号 - MGC12802
- Leu-12
- CD19
- B4
UniProt编号 - P15391
UniProt汇总 FUNCTION: SwissProt: P15391 # Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
SIZE: 556 amino acids; 61128 Da
SUBUNIT: Forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
DISEASE:SwissProt: P15391 # Defects in CD19 are a cause of hypogammaglobulinemia [MIM:107265].
SIMILARITY: SwissProt: P15391 ## Contains 2 Ig-like C2-type (immunoglobulin-like) domains.产品使用声明 使用声明 - Minimum order quantity required to qualify. Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C. 包装信息 数量 Bulk packaging. Please inquire.
上一件merck millipore产品：merck millipore,默克密理博,JH-10L-BK,Anti-A from the clone BIRMA-1, Murine IgM, Intermediate for further manufacturing use
下一件merck millipore产品：merck millipore,默克密理博,TB-10X2ML-U,BIOSCOT Anti-s from the clone P3BER, Human IgM, Blood Grouping Reagent
