merck millipore,默克密理博,04-1032,Anti-Neurofilament-66 Antibody, clone EP676Y, rabbit monoclonal

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merck millipore,默克密理博,04-1032,Anti-Neurofilament-66 Antibody, clone EP676Y, rabbit monoclonal
产品名称：Anti-Neurofilament-66 Antibody, clone EP676Y, rabbit monoclonal
产品型号：04-1032
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target.

merck millipore,默克密理博,04-1032,Anti-Neurofilament-66 Antibody, clone EP676Y, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-1032,Anti-Neurofilament-66 Antibody, clone EP676Y, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, H	FC, WB, ICC	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	04-1032
描述	Anti-Neurofilament-66 Antibody, clone EP676Y, rabbit monoclonal
Alternate Names	neurofilament-66, tax-binding protein 66 kDa neurofilament protein internexin neuronal intermediate filament protein, alpha neurofilament 5 (66kD)
背景信息	Neurofilament-66, also known as α-internexin, is a member of the IF family. It is found in developing neuroblasts and in the CNS of adults. Neurofilament-66 is expressed in the adult brain at lower levels than other neurofilament proteins.

产品信息
格式	Unpurified
控制	SHSY5Y cell lysate
演示	Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target.
主要应用	Flow Cytometry Western Blotting Immunocytochemistry
应用说明	Immunohistochemistry Analysis: A 1:250-500 dilution from a previous lot detected Neurofilament-66 in human brain tissue but not in human colon, kidney or uterus. Immunocytochemistry Analysis: A 1:250 - 500 dilution from a previous lot detected Neurofilament-66 in PC12 cells. Flow Cytometry: A 1:25 dilution of a previous lot was used in flow cytometry. Immunoprecipitation Analysis: A 1:50 dilution from a previous lot was used in IP.

生物信息
免疫原品种	Synthetic peptide corresponding to residues in the tail domain of human Neurofilament-66.
表位	Tail Domain
克隆	EP676Y
宿主	Rabbit
特异性	This antibody recognizes Neurofilament-66 at and around the tail domain.
同种型	IgG
品种反应性	RatHuman
Species Reactivity Note	Human and rat.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_116116.1
Entrez基因汇总	Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons.
基因符号	TXBP-1 Alpha-Inx FLJ18662 FLJ57501 MGC12702 NEF5 NF-66 Neurofilament-66 OTTHUMP00000020403
纯化方法	Unpurified
UniProt编号	Q16352
UniProt汇总	FUNCTION: Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges. TISSUE SPECIFICITY: Found predominantly in adult CNS. DEVELOPMENTAL STAGE: Expressed in brain as early as the 16th week of gestation, and increased rapidly and reached a steady state level by the 18th week of gestation. PTM: O-glycosylated By similarity. Phosphorylated upon DNA damage, probably by ATM or ATR. SEQUENCE SIMILARITIES: Belongs to the intermediate filament family.

产品使用声明
质量保证	Evaluated by Western Blot on SHSY5Y cell lysates. Western Blot Analysis: 1:5,000-10,000 dilution of this antibody was used to detect Neurofilament-66 in SHSY5Y cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20ºC from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.