merck millipore,默克密理愽
  • merck millipore,默克密理博,16-210,Anti-ZAP-70 Antibody, clone 2F3.2, FITC conjugate

  • merck millipore,默克密理博,16-210,Anti-ZAP-70 Antibody, clone 2F3.2, FITC conjugate

    产品名称：Anti-ZAP-70 Antibody, clone 2F3.2, FITC conjugate
    产品型号：16-210
    Anti-ZAP-70 Antibody, clone 2F3.2, FITC conjugate detects level of ZAP-70 & has been published & validated for use in FC, IC & WB.

    merck millipore,默克密理博,16-210,Anti-ZAP-70 Antibody, clone 2F3.2, FITC conjugate

  • 产品介绍
  • merck millipore,默克密理博,16-210,Anti-ZAP-70 Antibody, clone 2F3.2, FITC conjugate

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, HWB, FC, ICCMFITCMonoclonal Antibody
    描述
    产品目录编号 16-210
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-ZAP-70 Antibody, clone 2F3.2, FITC conjugate
    概述 Note: This product is for research use only. It is not manufacured for diagnostic or therapeutic use in humans or animals

    Product Description: Protein G purified mouse IgG2a, Catalog # 05-253, conjugated to fluorescein isothiocyanate (FITC)

    Immunogen: GST-fusion protein containing the 2 tandem SH2 domains of human ZAP-70 corresponding to amino acids 1-254
    Alternate Names
    • zeta-chain associated protein kinase, 70kD
    • 70 kDa zeta-associated protein
    • Syk-related tyrosine kinase
    • zeta-chain (TCR) associated protein kinase (70 kD)
    • zeta-chain (TCR) associated protein kinase 70kDa
    • zeta-chain associated protein kinase 70kDa
    • zeta-chain associated protein kinase
    背景信息 ZAP70, a 70 kDa member of the Syk tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. Mutations in ZAP70 gene results in a form of Severe Combined Immunodeficiency Syndrome (SCID) in humans. ZAP70 expression also defines a subset of Chronic Lymphocytic Leukemia (CLL) in patients with unmutated Ig gene and poor clinical course.
    产品信息
    格式 FITC
    控制
    • Western Blot: Jurkat cell lysate.
    演示 Mouse monoclonal FITC-conjugated IgG2a in buffer containing PBS containing 0.05% sodium azide.

    Protein G purified mouse IgG2a, Catalog # 05-253, conjugated to fluorescein isothiocyanate (FITC). Note: This product is for research use only. It is not manufacured for diagnostic or therapeutic use in humans or animals.
    应用
    应用 Anti-ZAP-70 Antibody, clone 2F3.2, FITC conjugate detects level of ZAP-70 & has been published & validated for use in FC, IC & WB.
    主要应用
    • Western Blotting
    • Flow Cytometry
    • Immunocytochemistry
    应用说明 Immunocytochemistry:
    5-20 µg/mL of a previous lot detected ZAP-70 in Jurkat cells fixed with formaldehyde and permeabilized with saponin.
    生物信息
    免疫原品种 GST-fusion protein containing the 2 tandem SH2 domains of human ZAP-70 correspon-ding to amino acids 1-254. Clone 2F3.2.
    克隆 clone 2F3.2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Recognizes human ZAP-70.
    同种型 IgG2a
    品种反应性 RatHuman
    Species Reactivity Note Human. Expected to cross-react with rat.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001070
    Entrez基因汇总 This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
    基因符号
    • SRK
    • ZAP70
    • ZAP-70
    • TZK
    • STD
    纯化方法 Protein G purfied
    UniProt编号
    • P43403
    UniProt汇总 FUNCTION: SwissProt: P43403 # Associates with the T-cell antigen receptor zeta chain (CD3Z). Plays a role in lymphocyte activation.
    SIZE: 619 amino acids; 69872 Da
    SUBUNIT: Interacts with SLA2 when it is phosphorylated. Interacts with CD3Z and with phosphorylated NFAM1. Interacts with CBLB (By similarity). Interacts with CBL and SLA when it is phosphorylated. The association with SLA (or SLA2) and CBL probably leads to its destruction. Interacts with SHB. Interacts with DEF6 (By similarity).
    TISSUE SPECIFICITY: Expressed in T- and natural killer cells.
    DOMAIN: SwissProt: P43403 The SH2 domain binds to the phosphorylated tyrosine-based activation motif (TAM) of CD3Z.
    PTM: Phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation. Tyr-319 phosphorylation is essential for full activity.
    DISEASE:SwissProt: P43403 # Defects in ZAP70 are the cause of selective T-cell defect (STD) [MIM:176947]. STD is an autosomal recessive form of severe combined immunodeficiency characterized by a selective absence of CD8-type T-cells.
    SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily. & Contains 1 protein kinase domain. & Contains 2 SH2 domains.
    产品使用声明
    质量保证 Routinely evaluated by Western Blot on Jurkat lysates.

    Western Blot Analysis:
    1:500 dilution of this lot detected ZAP 70 on 10 μg of Jurkat lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 6 months at 2-8°C from date of receipt. For maximum recovery of product, centrifuge original vial prior to removing cap.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,16-210,Anti-ZAP-70 Antibody, clone 2F3.2, FITC conjugate

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