merck millipore,默克密理愽
  • merck millipore,默克密理博,14-463,PDGFRβ Protein, active, 50 µg

  • merck millipore,默克密理博,14-463,PDGFRβ Protein, active, 50 µg

    产品名称：PDGFRβ Protein, active, 50 µg
    产品型号：14-463
    Active, recombinant human PDGF Receptor β, residues 557-end, containing an N-terminal His6-tag, for use in Kinase Assays.

    merck millipore,默克密理博,14-463,PDGFRβ Protein, active, 50 µg

  • 产品介绍
  • merck millipore,默克密理博,14-463,PDGFRβ Protein, active, 50 µg

    描述
    产品目录编号 14-463
    品牌系列 Upstate
    商名
    • Upstate
    描述 PDGFRβ Protein, active, 50 µg
    概述 Recombinant human PDGF Receptor β, residues 557 end, containing an Nterminal His6-tag
    应用
    应用 Active, recombinant human PDGF Receptor β, residues 557-end, containing an N-terminal His6-tag, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Expressed by baculovirus in Sf21 insect cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_002609.3
    Entrez基因汇总 This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
    基因符号
    • PDGF-R-beta
    • PDGFRB
    • PDGFR1
    • CD140b
    • PDGFR
    • JTK12
    • CD140B
    蛋白靶 PDGFRβ
    纯化方法 Ni2+/NTA-agarose
    靶子系列 TK
    UniProt编号
    • P09619
    UniProt汇总 FUNCTION: SwissProt: P09619 # Receptor that binds specifically to PDGFB and PDGFD and has a tyrosine-protein kinase activity. Phosphorylates Tyr residues at the C-terminus of PTPN11 creating a binding site for the SH2 domain of GRB2.
    SIZE: 1106 amino acids; 123968 Da
    SUBUNIT: Homodimer, and heterodimer with PDGFRA. Interacts with APS. The autophosphorylated form interacts directly with SHB and with PIK3C2B, maybe indirectly.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    DISEASE: SwissProt: P09619 # A chromosomal aberration involving PDGFRB is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;12)(q33;p13) with EVT6/TEL. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML). & A chromosomal aberration involving PDGFRB may be a cause of acute myelogenous leukemia. Translocation t(5;14)(q33;q32) with TRIP11. The fusion protein may be involved in clonal evolution of leukemia and eosinophilia. & A chromosomal aberration involving PDGFRB may be a cause of juvenile myelomonocytic leukemia. Translocation t(5;17)(q33;p11.2) with SPECC1. & A chromosomal aberration involving PDGFRB is a cause in many instances of chronic myeloproliferative disorder with eosinophilia (MPE) [MIM:131440]. Translocation t(5;12) with ETV6 on chromosome 12 creating an PDGFRB-ETV6 fusion protein. & A chromosomal aberration involving PDGFRB may be the cause of a myeloproliferative disorder (MBD) associated with eosinophilia. Translocation t(1;5)(q23;q33) that forms a PDE4DIP- PDGFRB fusion protein.
    SIMILARITY: SwissProt: P09619 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of Poly (Glu4-Tyr) substrate peptide
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at 70 °C
    包装信息
    数量 50 µg

    merck millipore,默克密理博,14-463,PDGFRβ Protein, active, 50 µg

上一件merck millipore产品：merck millipore,默克密理博,HTS071RTA,Ready-to-Assay™ ChemR23 Chemoattractant Receptor Frozen Cells
下一件merck millipore产品：merck millipore,默克密理博,14-677,PRKX Protein, active, 10 µg


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