merck millipore,默克密理愽
  • merck millipore,默克密理博,603425,Threonine Dehydrogenase Inhibitor, QC1 - CAS 403718-45-6 - Calbiochem

  • merck millipore,默克密理博,603425,Threonine Dehydrogenase Inhibitor, QC1 - CAS 403718-45-6 - Calbiochem

    产品名称：Threonine Dehydrogenase Inhibitor, QC1 - CAS 403718-45-6 - Calbiochem
    产品型号：603425
    The Threonine Dehydrogenase Inhibitor, QC1 controls the biological activity of Threonine Dehydrogenase.

    merck millipore,默克密理博,603425,Threonine Dehydrogenase Inhibitor, QC1 - CAS 403718-45-6 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,603425,Threonine Dehydrogenase Inhibitor, QC1 - CAS 403718-45-6 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₃H₁₆F₃N₃O₂S403718-45-6
    描述
    概述 A cell-permeable quinazolinecarboxamide (QC) compound that acts as a potent, reversible and mixed noncompetitive inhibitor of threonine dehydrogenase activity (IC50 ~ 0.5 µM for mTDH) with excellent selectivity over hydroxysteroid, alcohol, lactate, or glucose-6-phosphate dehydrogenases (IC50 >10 µM). Shown to block threonine catabolism, induce autophagy and impede the growth of highly proliferating mouse embryonic stem cells (mESCs; EC50 ~3 µM) with no effect on ESCs-derived embryoid body cells, 3T3 fibroblasts or tumor cells (EC50 ~1 mM).
    产品目录编号 603425
    品牌系列 Calbiochem®
    同义词 N-Benzyl-4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinazoline-7-carboxamide
    参考
    参考 Alexander, P.B., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 15828.
    产品信息
    CAS号 403718-45-6
    形式 White powder
    Hill配方 C₂₃H₁₆F₃N₃O₂S
    化学配方 C₂₃H₁₆F₃N₃O₂S
    Molar Mass 455.5
    结构配方图像
    生物信息
    纯度 ≥96% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,603425,Threonine Dehydrogenase Inhibitor, QC1 - CAS 403718-45-6 - Calbiochem

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