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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB, FC Rb Purified Monoclonal Antibody 描述 产品目录编号 04-382 品牌系列 Upstate
商名 - Upstate
描述 Anti-MKK4 CT Antibody, rabbit monoclonal Alternate Names - JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SEK1, SERK1
- JNKK
- JNKK1
- MAPKK4
- MEK4
- MKK4
- PRKMK4
- SEK1
产品信息 格式 Purified 演示 Rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 90 mM NaCl, 0.006% sodium azide, 0.03% BSA and 40% glycerol. 应用 应用 Anti-MKK4 CT Antibody is an antibody against MKK4 CT for use in FC, IH(P), IP & WB. 主要应用 - Western Blotting
- Flow Cytometry
应用说明 Western Blot: 1:1000.
Immunoprecipitation: 1:50. The use of protein G agarose is recommended.
Flow Cytometry: 1:50.
Immunohistochemistry: 1:50-1:100 on paraffin-embeddedsections of human lung adenocarcinoma.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 KLH-conjugated synthetic peptide corresponding to residues in the C-term of human MKK4. 表位 C-terminus 宿主 Rabbit 特异性 Recognizes MKK4. 同种型 IgG 品种反应性 RatHumanMouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_003010.2
Entrez基因汇总 This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. 基因符号 - JNKK
- MAP2K4
- SERK1
- MAPKK4
- JNKK1
- SEK1
- PRKMK4
- MEK4
- MKK4
纯化方法 Protein G purfied UniProt编号 - P45985
UniProt汇总 FUNCTION: SwissProt: P45985 # Dual specificity kinase that activates the JUN kinases MAPK8 (JNK1) and MAPK9 (JNK2) as well as MAPK14 (p38) but not MAPK1 (ERK2) or MAPK3 (ERK1).
SIZE: 399 amino acids; 44288 Da
SUBUNIT: Interacts with SPAG9 (By similarity).
TISSUE SPECIFICITY: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
PTM: Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases (By similarity).
SIMILARITY: SwissProt: P45985 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain.产品使用声明 质量保证 Routinely evaluated by immunoblot analysis. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C from date of shipment. 包装信息 数量 100 µL
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