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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB, ICC Rb Serum Polyclonal Antibody 描述 产品目录编号 AB15417 Replaces MABN16 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Beclin 1 Antibody Alternate Names - Coiled-coil myosin-like BCL2-interacting protein, BECN1
- Coiled-coil myosin-like BCL2-interacting protein
背景信息 Autophagy is the process by which cells recycle cytoplasm and dispose of excess or defective organelles. This process is suggested to be involved development, differentiation, growth regulation and tissue remodeling in multicellular organisms. Beclin 1 is a BCL-2 interacting protein and this protein was shown to play a role in the promotion of autophagy. 产品信息 格式 Serum 演示 Lyophilized. Reconstitute with 50 μL of sterile distilled water. Centrifuge to remove any insoluble material. Contains no preservative. 应用 应用 Detect Beclin 1 using this Anti-Beclin 1 Antibody validated for use in WB, IC, IH. 主要应用 - Immunohistochemistry
- Western Blotting
- Immunocytochemistry
应用说明 Western blot: 1:100-1:2,000
Immunocytochemistry: 1:100-1:2,000
Immunohistochemistry: 1:100-1:2,000
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide corresponding to the C-terminus of human Beclin 1 protein. 宿主 Rabbit 特异性 Beclin 1 [Coiled-coil myosin-like BCL2-interacting protein, BECN1]. 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_003766.2
基因符号 - VPS30
- BECN1
- GT197
- Beclin-1
- beclin1
- ATG6
纯化方法 Serum UniProt编号 - Q14457
UniProt汇总 FUNCTION: SwissProt: Q14457 # May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus. May play a role in autophagy.
SIZE: 450 amino acids; 51896 Da
SUBUNIT: Interacts with GOPC and GRID2 (By similarity). Interacts with BCL2 and BCL2L1.
SUBCELLULAR LOCATION: Cytoplasm (Potential). Golgi apparatus membrane; Peripheral membrane protein (By similarity). Note=Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity).
TISSUE SPECIFICITY: Ubiquitous.
SIMILARITY: SwissProt: Q14457 ## Belongs to the beclin family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain lyophilized material frozen at -20°C to -70°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1, ACS or better grade) can be added for additional stability. 包装信息 数量 50 µL
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