merck millipore,默克密理愽
  • merck millipore,默克密理博,573132,STAT3 Inhibitor XVIII, BP-1-102 - Calbiochem

  • merck millipore,默克密理博,573132,STAT3 Inhibitor XVIII, BP-1-102 - Calbiochem

    产品名称：STAT3 Inhibitor XVIII, BP-1-102 - Calbiochem
    产品型号：573132
    The STAT3 Inhibitor XVIII, BP-1-102 controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,573132,STAT3 Inhibitor XVIII, BP-1-102 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,573132,STAT3 Inhibitor XVIII, BP-1-102 - Calbiochem

    重要规格表

    经验配方
    C₂₉H₂₇F₅N₂O₆S
    描述
    概述 A cell-permeable, orally bioavailable amidosalicylic acid compound that selectively binds the three subpockets of Stat3 SH2 domain surface (KD = 504 nM) and blocks Stat3 phosphorylation, dimerization, and DNA-binding activity in a dose-dependent manner. Preferentially disrupts the high affinity binding between Stat3 and IL-6R/gp130-derived pTyr904 peptide (IC50 = 4.1 µM). Does not exert any significant effect on the phosphorylation status of Shc, Src, JAK1/2, Erk1/2, or Akt. Shown to reduce Stat3-dependent growth, survival, migration, and invasion of tumor cells in vitro and suppress the growth of aberrant Stat3-harboring human breast and lung tumor xenografts (3 mg/kg, i,v. or o.g.) in vivo.
    产品目录编号 573132
    品牌系列 Calbiochem®
    同义词 4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid
    参考
    参考 Zhang, X., et al. Proc. Natl. Acad. Sci. USA 109, 9623.
    产品信息
    形式 White powder
    Hill配方 C₂₉H₂₇F₅N₂O₆S
    化学配方 C₂₉H₂₇F₅N₂O₆S
    Molar Mass 626.6
    可逆 Y
    结构配方图像
    生物信息
    主靶 Stat3
    纯度 ≥97% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,573132,STAT3 Inhibitor XVIII, BP-1-102 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,20-106,pNPP (p-Nitrophenyl Phosphate)
下一件merck millipore产品：merck millipore,默克密理博,524653,PBS-TWEEN Tablets - Calbiochem


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