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merck millipore,默克密理博,658460,AG 879 - CAS 148741-30-4 - Calbiochem
产品名称：AG 879 - CAS 148741-30-4 - Calbiochem
产品型号：658460
A cell-permeable, reversible, and substrate competitive inhibitor of nerve growth factor (NGF)-dependent p140c-trk tyrosine phosphorylation (EC₅₀ = 10 µM) as well as NGF-induced phos More>>
merck millipore,默克密理博,658460,AG 879 - CAS 148741-30-4 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₈H₂₄N₂OS 148741-30-4 描述 概述 A cell-permeable, reversible, and substrate competitive inhibitor of nerve growth factor (NGF)-dependent p140c-trk tyrosine phosphorylation (EC50 = 10 µM) as well as NGF-induced phospholipase C-γ1 phosphorylation. Also blocks NGF-induced neurite outgrowth in PC12 cells. Does not affect the tyrosine phosphorylation of epidermal growth factor receptor or platelet-derived growth factor receptor. Inhibits insulin secretion in a dose-dependent manner. 产品目录编号 658460 品牌系列 Calbiochem®
同义词 α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide 参考 参考 Konrad, R.J., et al. 1996. J. Biol. Chem. 271, 24179.
Levitzki, A. and Gazit, A. 1995. Science. 267, 1782.
Ohmichi, M., et al. 1993. Biochemistry 32, 4650.产品信息 CAS号 148741-30-4 具有ATP竞争性 N 形式 Orange-yellow solid Hill配方 C₁₈H₂₄N₂OS 化学配方 C₁₈H₂₄N₂OS Molar Mass 316.5 可逆 Y 结构配方图像 生物信息 主靶 (NGF)-dependent p140c-trk tyrosine phosphorylation 主靶IC50 EC50 = 10 µM inhibiting nerve growth factor (NGF)-dependent p140c-trk tyrosine phosphorylation 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
From Catalog:
Solubility- removed acetic acid, MeOH
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