merck millipore,默克密理博,573131,STAT3 Inhibitor XIV, LLL12

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Merck Millipore 默克密理愽

merck millipore,默克密理博,573131,STAT3 Inhibitor XIV, LLL12 - Calbiochem

经验配方
C₁₄H₉NO₅S

描述
概述	A cell-permeable hydroxyanthraquinone compound that binds directly to the phosphoryl Tyr⁷⁰⁵ binding site of the STAT3 monomer and acts as selective and reversible inhibitor of STAT3 signaling. Shown to block STAT3 phosphorylation and its subsequent nuclear localization and DNA binding, but has no effect on IL-4, interferon-α and interferon-γ-induced STAT1, 2, 4, 6 and pJAK2, PI3-Kinase, or ERK signaling. Does not affect the activity of over 21 other closely related protein kinases (IC₅₀ > 50 µM). Also shown to induce apoptosis in U266 and ARH-77 multiple myeloma cell lines (IC₅₀ = 490 nM and 1.96 µM, respectively), and suppress hepatocellular carcinoma tumor growth in xenograft mouse model (5 mg/kg, i.v).
产品目录编号	573131
品牌系列	Calbiochem®
同义词	5-Hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-sulfonamide

参考
参考	Lin, L., et al. 2011. Cancer Res. 71, 7226. Lin, L., et al. 2011. Int. J. Cancer in press. Ball, S., et al. PLoS One 6, e18820. Liu, Y., et al. 2010. J. Biol. Chem. 285, 27429. Lin, L., et al. 2010. Neoplasia 12, 39.

生物信息
纯度	≥98% by HPLC

理化信息
溶解度	DMSO

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,573131,STAT3 Inhibitor XIV, LLL12 - Calbiochem

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