merck millipore,默克密理愽
  • merck millipore,默克密理博,06-572,Anti-erbB-4/HER-4 Antibody

  • merck millipore,默克密理博,06-572,Anti-erbB-4/HER-4 Antibody

    产品名称：Anti-erbB-4/HER-4 Antibody
    产品型号：06-572
    Anti-erbB-4/HER-4 Antibody is an antibody against erbB-4/HER-4 for use in IP & WB.

    merck millipore,默克密理博,06-572,Anti-erbB-4/HER-4 Antibody

  • 产品介绍
  • merck millipore,默克密理博,06-572,Anti-erbB-4/HER-4 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 06-572
    Replaces 04-348
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-erbB-4/HER-4 Antibody
    产品信息
    格式 Purified
    演示 10mM PBS, pH 7.4, with 0.05% sodium azide
    应用
    应用 Anti-erbB-4/HER-4 Antibody is an antibody against erbB-4/HER-4 for use in IP & WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 peptide corresponding to the C-terminus amino acids 1285 to 1308 of human erbB-4/HER-4
    宿主 Rabbit
    特异性 erbB-4/HER-4; will not cross react with erbB-1(EGF R), erbB-2 or erbB-3
    同种型 IgG
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_005235
    Entrez基因汇总 This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
    基因符号
    • MGC138404
    • ERBB4
    • p180erbB4
    • HER4
    纯化方法 Protein A chromatography
    UniProt编号
    • Q15303
    UniProt汇总 FUNCTION: SwissProt: Q15303 # Specifically binds and is activated by neuregulins, NRG- 2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. Interaction with these factors induces cell differentiation. Not activated by EGF, TGF-A, and amphiregulin.
    SIZE: 1308 amino acids; 146808 Da
    SUBUNIT: Homodimer or heterodimer with each of the other ERBB receptors (Potential). Interacts with PDZ domains of DLG2, DLG3, DLG4 and the syntrophin SNTB2. Interacts with CBFA2T3 and WWOX.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    TISSUE SPECIFICITY: Expressed at highest levels in brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. Lower levels in thymus, lung, salivary gland, and pancreas.
    DOMAIN:SwissProt: Q15303 The WW-binding motifs mediate interaction with WWOX.
    PTM: Ligand-binding increases phosphorylation on tyrosine residues.
    SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on RIPA lysates from MDA-MB-453 cells or RIPA lysates from MCF-7 cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 200 µg

    merck millipore,默克密理博,06-572,Anti-erbB-4/HER-4 Antibody

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